@article{eb518ac94f224f08aa463f4872edc281,
title = "TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors",
abstract = "Whole-genome sequencing detected structural rearrangements of TERT in 17 of 75 high-stage neuroblastomas, with five cases resulting from chromothripsis. Rearrangements were associated with increased TERT expression and targeted regions immediately up- and downstream of TERT, positioning a super-enhancer close to the breakpoints in seven cases. TERT rearrangements (23\%), ATRX deletions (11\%) and MYCN amplifications (37\%) identify three almost non-overlapping groups of high-stage neuroblastoma, each associated with very poor prognosis. ",
keywords = "DNA Helicases/genetics, Gene Amplification, Gene Deletion, Gene Expression Regulation, Neoplastic, Gene Rearrangement, Genome, Human, High-Throughput Nucleotide Sequencing/methods, Humans, N-Myc Proto-Oncogene Protein, Neuroblastoma/genetics, Nuclear Proteins/genetics, Oncogene Proteins/genetics, Telomerase/genetics, Telomere/genetics, X-linked Nuclear Protein",
author = "Valentijn, \{Linda J\} and Jan Koster and Zwijnenburg, \{Danny A\} and Hasselt, \{Nancy E\} and \{van Sluis\}, Peter and Richard Volckmann and \{van Noesel\}, \{Max M\} and George, \{Rani E\} and Tytgat, \{Godelieve A M\} and Molenaar, \{Jan J\} and Rogier Versteeg",
note = "Publisher Copyright: {\textcopyright} 2015 Nature America, Inc. All rights reserved.",
year = "2015",
month = dec,
doi = "10.1038/ng.3438",
language = "English",
volume = "47",
pages = "1411--4",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "12",
}