TY - JOUR
T1 - TFIIH
T2 - A key component in multiple DNA transactions
AU - Hoeijmakers, Jan H.J.
AU - Egly, Jean Marc
AU - Vermeulen, Wim
N1 - Funding Information:
We gratefully acknowledge the stimulating discussions wirh all members of our laboratories as well as other colleagues. Our research is supported by the Dutch Scientific Organizarions NW0 and SON, the Dutch Cancer Society. Human Frontiers and rhe Louis Jeantet Foundation. Finally, we sincerely apologize for rhe restricred number of references and the emphasis on recent literature rhat is required for rhe formar of this review, resulting in undereitacion of older literature and frequent reference to reviews.
PY - 1996
Y1 - 1996
N2 - The transcription factor TFIIH is a versatile, multi-functional protein complex with multiple engagements. Apart from its role in basal transcription, TFIIH is intimately implicated in DNA repair and (probably) in cell cycle control (both of which are required to prevent carcinogenesis) as well as having possible roles in other processes. Thus, it is a striking example of the efficient use of one component for many purposes. Ingeniously, the incorporation of this essential factor into important, but non-essential, mechanisms, such as DNA repair, protects against cancer. The critical role of TFIIH in transcription function renders inactivating TFIIH mutations lethal to cells. Without this transcription connection, such mutations would lead to genetic instability and oncogenesis.
AB - The transcription factor TFIIH is a versatile, multi-functional protein complex with multiple engagements. Apart from its role in basal transcription, TFIIH is intimately implicated in DNA repair and (probably) in cell cycle control (both of which are required to prevent carcinogenesis) as well as having possible roles in other processes. Thus, it is a striking example of the efficient use of one component for many purposes. Ingeniously, the incorporation of this essential factor into important, but non-essential, mechanisms, such as DNA repair, protects against cancer. The critical role of TFIIH in transcription function renders inactivating TFIIH mutations lethal to cells. Without this transcription connection, such mutations would lead to genetic instability and oncogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0030023261&partnerID=8YFLogxK
U2 - 10.1016/S0959-437X(96)90006-4
DO - 10.1016/S0959-437X(96)90006-4
M3 - Article
C2 - 8791490
AN - SCOPUS:0030023261
SN - 0959-437X
VL - 6
SP - 26
EP - 33
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 1
ER -