TGF-β signaling is dynamically regulated during the alveolarization of rodent and human lungs

Miguel A. Alejandre-Alcázar, Matthias Michiels-Corsten, Alfin G. Vicencio, Irwin Reiss, Julie Ryu, Ronald R. De Krijger, Gabriel G. Haddad, Dick Tibboel, Werner Seeger, Oliver Eickelberg, Rory E. Morty

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

84 Citaten (Scopus)


Although transforming growth factor-beta (TGF-β) signaling negatively regulates branching morphogenesis in early lung development, few studies to date have addressed the role of this family of growth factors during late lung development. We describe here that the expression, tissue localization, and activity of components of the TGF-β signaling machinery are dynamically regulated during late lung development in the mouse and human. Pronounced changes in the expression and localization of the TGF-β receptors Acvrl1, Tgfbr1, Tgfbr2, Tgfbr3, and endoglin, and the intracellular messengers Smad2, Smad3, Smad4, Smad6, and Smad7 were noted as mouse and human lungs progressed through the canalicular, saccular, and alveolar stages of development. TGF-β signaling, assessed by phosphorylation of Smad2, was detected in the vascular and airway smooth muscle, as well as the alveolar and airway epithelium throughout late lung development. These data suggest that active TGF-β signaling is required for normal late lung development.

Originele taal-2Engels
Pagina's (van-tot)259-269
Aantal pagina's11
TijdschriftDevelopmental Dynamics
Nummer van het tijdschrift1
StatusGepubliceerd - jan. 2008
Extern gepubliceerdJa


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