The case for Survivin as mitotic regulator

Susanne M A Lens, Gerben Vader, René H Medema

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review


Survivin has been proposed to inhibit apoptosis and to regulate cell division. However, controversy still exists as to whether Survivin can indeed execute these distinct functions and if Survivin somehow coordinates apoptosis and (abnormal) cell division. Recent evidence has demonstrated that Survivin acts as a subunit of the chromosomal passenger complex, which is essential for proper chromosome segregation and cytokinesis. Within this complex, the mitotic kinase Aurora B acts as the enzymatic core, whereas Survivin dictates chromosomal passenger complex localization. This function of Survivin appears to be conserved throughout evolution. Although these findings do not exclude a role for Survivin as apoptosis inhibitor, they make a very strong case for Survivin as mitotic regulator.

Originele taal-2Engels
Pagina's (van-tot)616-22
Aantal pagina's7
TijdschriftCurrent Opinion in Cell Biology
Nummer van het tijdschrift6
StatusGepubliceerd - dec. 2006
Extern gepubliceerdJa


Duik in de onderzoeksthema's van 'The case for Survivin as mitotic regulator'. Samen vormen ze een unieke vingerafdruk.

Citeer dit