@article{0c6cc06dc57445d88648a0d7880b94bb,
title = "The effect of retinoic acid on the activation of the human H19 promoter by a 3' downstream region",
abstract = "The human H19 is paternally imprinted (maternally expressed). It is transcribed by RNA pol II, but has no protein product. Its function is unknown. We showed that the transcription of the human H19 gene is under the simultaneous control of both a 5' upstream (promoter) region and a 3' downstream region in cell lines derived from human choriocarcinomas. Moreover, the activation of the H19 promoter by retinoic acid in cells derived from human testicular germ cell tumors is dependent upon the 3' downstream region. The possibility that the action of retinoic acid on the H19 promoter is an indirect one and involves a member of the AP2 transcription factor family is discussed.",
keywords = "Antineoplastic Agents/pharmacology, Chloramphenicol O-Acetyltransferase/drug effects, DNA, Neoplasm/genetics, Enhancer Elements, Genetic/drug effects, Gene Expression Regulation/drug effects, Gene Expression Regulation, Neoplastic/drug effects, Humans, Muscle Proteins/drug effects, Promoter Regions, Genetic/drug effects, RNA, Long Noncoding, RNA, Untranslated, Recombinant Proteins/drug effects, Simian virus 40/genetics, Transcription, Genetic/drug effects, Transfection, Tretinoin/pharmacology, Tumor Cells, Cultured/cytology",
author = "E Kopf and O Bibi and S Ayesh and M Tykocinski and K Vitner and Looijenga, {L H} and {de Groot}, N and A Hochberg",
note = "Funding Information: We are greatly indebted to Dr. S.M. Tilghman (Princeton, USA) for providing us with the SacI fragment of the human 3′ H19 downstream region and her continued interest in our work. This work was supported by a grant from the USA-Israel Binational Science Foundation (No. 95-00163), by the Cooperation Program in Cancer Research between the Deutsches Krebsforschungzentrum (DKFZ), Heidelberg, Germany and the Israel's Ministry of Science and the Arts and the German-Israeli-Palestinian Authority Trilateral grant sponsored by the Deutsche Forschungsgemeinschaft (DFG), and by NIH grant No. (1RO1CA69646-01A1).",
year = "1998",
month = aug,
day = "7",
doi = "10.1016/s0014-5793(98)00841-2",
language = "English",
volume = "432",
pages = "123--7",
journal = "FEBS letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "3",
}