The emerging era of targeted therapy in childhood acute lymphoblastic leukemia

William L. Carroll, Rob Pieters

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukpeer review

2 Citaten (Scopus)


One of the most fundamental goals of modern cancer research is to develop more effective therapies that specifically target the cancer cell while sparing normal cells from the collateral damage that is common to conventional therapies. The cornerstone of current cancer treatment depends on drugs associated with a very narrow therapeutic index in that the effective dose and the toxic dose frequently overlap. While progress in pediatric oncology, specifically, improved cure rates for the most common childhood malignancy, acute lymphoblastic leukemia (ALL), has outpaced improvements in other cancer subtypes, treatment for ALL still relies on conventional cytotoxic agents thereby exposing children to considerable short- and long-term side effects.

Originele taal-2Engels
TitelMolecularly Targeted Therapy for Childhood Cancer
UitgeverijSpringer New York
Aantal pagina's16
ISBN van geprinte versie9780387690605
StatusGepubliceerd - 2010
Extern gepubliceerdJa


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