The genes for variant antigens in trypanosomes

P. Borst; A. C.C. Frasch; A. Bernards; J. H. Hoeijmakers; L. H. Van der Ploeg; G. A. Cross

doi:10.4269/ajtmh.1980.29.1033

The genes for variant antigens in trypanosomes

P. Borst, A. C.C. Frasch, A. Bernards, J. H. Hoeijmakers, L. H. Van der Ploeg, G. A. Cross

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

15 Citaten (Scopus)

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We have studied the mechanism of antigenic variation by using DNA complementary to the messenger RNAs for four variant surface glycoproteins of Trypansoma brucei. Pure complementary DNAs were obtained by cloning as recombinant DNA in Escherichia coli. Using these complementary DNAs as hybridization probes, we have analyzed the genes for these variant surface glycoproteins. The results provide new information on the origin and evolution of antigenic variation, and on the mechanism involved in switching from one antigenic type to another.

Originele taal-2	Engels
Pagina's (van-tot)	1033-1036
Aantal pagina's	4
Tijdschrift	Unknown Journal
Volume	29
Nummer van het tijdschrift	5 II
DOI's	https://doi.org/10.4269/ajtmh.1980.29.1033
Status	Gepubliceerd - 1980
Extern gepubliceerd	Ja

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10.4269/ajtmh.1980.29.1033

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AU - Cross, G. A.

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The genes for variant antigens in trypanosomes

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