The human TRIDENT/HFH- 11/FKHL16 gene: Structure, localization, and promoter characterization

Wouter Korver; Jeroen Roose; Klaartje Heinen; Daniël Olde Weghuis; Diederik De Bruijn; Ad Geurts Van Kessel; Hans Clevers

doi:10.1006/geno.1997.5065

The human TRIDENT/HFH- 11/FKHL16 gene: Structure, localization, and promoter characterization

Wouter Korver
, Jeroen Roose
, Klaartje Heinen
, Daniël Olde Weghuis
, Diederik De Bruijn
, Ad Geurts Van Kessel
, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

109 Citaten (Scopus)

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We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here we report the isolation and characterization of the human TRIDENT (HGMW-approved symbol FKHL16) cDNA and gene. Homology between the human and the mouse Trident proteins was 79%. The gene consists of 10 exons and is located on chromosome 12 band p13. The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene.

Originele taal-2	Engels
Pagina's (van-tot)	435-442
Aantal pagina's	8
Tijdschrift	Genomics
Volume	46
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1006/geno.1997.5065
Status	Gepubliceerd - 15 dec 1997
Extern gepubliceerd	Ja

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10.1006/geno.1997.5065

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title = "The human TRIDENT/HFH- 11/FKHL16 gene: Structure, localization, and promoter characterization",

abstract = "We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here we report the isolation and characterization of the human TRIDENT (HGMW-approved symbol FKHL16) cDNA and gene. Homology between the human and the mouse Trident proteins was 79\%. The gene consists of 10 exons and is located on chromosome 12 band p13. The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene.",

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year = "1997",

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doi = "10.1006/geno.1997.5065",

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AU - Korver, Wouter

AU - Roose, Jeroen

AU - Heinen, Klaartje

AU - Weghuis, Daniël Olde

AU - Bruijn, Diederik De

AU - Van Kessel, Ad Geurts

AU - Clevers, Hans

PY - 1997/12/15

Y1 - 1997/12/15

N2 - We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here we report the isolation and characterization of the human TRIDENT (HGMW-approved symbol FKHL16) cDNA and gene. Homology between the human and the mouse Trident proteins was 79%. The gene consists of 10 exons and is located on chromosome 12 band p13. The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene.

AB - We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here we report the isolation and characterization of the human TRIDENT (HGMW-approved symbol FKHL16) cDNA and gene. Homology between the human and the mouse Trident proteins was 79%. The gene consists of 10 exons and is located on chromosome 12 band p13. The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene.

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DO - 10.1006/geno.1997.5065

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SN - 0888-7543

VL - 46

SP - 435

EP - 442

JO - Genomics

JF - Genomics

IS - 3

ER -

The human TRIDENT/HFH- 11/FKHL16 gene: Structure, localization, and promoter characterization

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