The intestinal stem cell

Nick Barker, Marc Van De Wetering, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

515 Citaten (Scopus)


The epithelium of the adult mammalian intestine is in a constant dialog with its underlying mesenchyme to direct progenitor proliferation, lineage commitment, terminal differentiation, and, ultimately, cell death. The epithelium is shaped into spatially distinct compart-ments that are dedicated to each of these events. While the intestinal epithelium represents the most vigorously renewing adult tissue in mammals, the stem cells that fuel this self-renewal process have been identified only recently. The unique epithelial anatomy makes the intestinal crypt one of the most accessible models for the study of adult stem cell biology. This review attempts to provide a comprehensive overview of four decades of research on crypt stem cells.

Originele taal-2Engels
Pagina's (van-tot)1856-1864
Aantal pagina's9
TijdschriftGenes and Development
Nummer van het tijdschrift14
StatusGepubliceerd - 15 jul. 2008
Extern gepubliceerdJa


Duik in de onderzoeksthema's van 'The intestinal stem cell'. Samen vormen ze een unieke vingerafdruk.

Citeer dit