The metabolic syndrome and its components in 178 patients treated for craniopharyngioma after 16 years of follow-up

Mark Wijnen, Daniel S. Olsson, Marry M. Van Den Heuvel-Eibrink, Casper Hammarstrand, Joseph A.M.J.L. Janssen, Aart Jan Van Der Lely, Gudmundur Johannsson, Sebastian J.C.M.M. Neggers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

41 Citaten (Scopus)

Samenvatting

Objective: Patients with craniopharyngioma are at an increased risk for cardio-and cerebrovascular mortality. The metabolic syndrome (MetS) is an important cardiometabolic risk factor, but barely studied in patients with craniopharyngioma. We aimed to investigate the prevalence of and risk factors for the MetS and its components in patients with craniopharyngioma. Design: Cross-sectional study with retrospective data. Methods: We studied the prevalence of and risk factors for the MetS and its components in 110 Dutch (median age 47 years, range 18-92) and 68 Swedish (median age 50 years, range 20-81) patients with craniopharyngioma with =3 years of follow-up (90 females (51%); 83 patients with childhood-onset craniopharyngioma (47%); median follow-up after craniopharyngioma diagnosis 16 years (range 3-62)). In Dutch patients aged 30-70 years and Swedish patients aged 45-69 years, we examined the prevalence of the MetS and its components relative to the general population. Results: Sixty-nine (46%) of 149 patients with complete data demonstrated the MetS. Prevalence of the MetS was signifcantly higher in patients with craniopharyngioma compared with the general population (40% vs 26% (P < 0.05) for Dutch patients; 52% vs 15% (P < 0.05) for Swedish patients). Multivariable logistic regression analysis identifed visual impairment as a borderline signifcant predictor of the MetS (OR 2.54, 95% CI 0.95-6.81; P = 0.06) after adjustment for glucocorticoid replacement therapy and follow-up duration. Age, female sex, tumor location, radiological hypothalamic damage, 90Yttrium brachytherapy, glucocorticoid replacement therapy and follow-up duration signifcantly predicted components of the MetS. Conclusions: Patients with craniopharyngioma are at an increased risk for the MetS, especially patients with visual impairment.

Originele taal-2Engels
Pagina's (van-tot)11-22
Aantal pagina's12
TijdschriftEuropean Journal of Endocrinology
Volume178
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - jan. 2018

Vingerafdruk

Duik in de onderzoeksthema's van 'The metabolic syndrome and its components in 178 patients treated for craniopharyngioma after 16 years of follow-up'. Samen vormen ze een unieke vingerafdruk.

Citeer dit