The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

Richard Roy, Jörg P. Adamczewski, Thierry Seroz, Wim Vermeulen, Jean Pierre Tassan, Laurent Schaeffer, Erich A. Nigg, Jan H.J. Hoeijmakers, Jean Marc Egly

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

403 Citaten (Scopus)

Samenvatting

A protein kinase activity that phosphorylates the C-terminal domain (CTD) of RNA polymerase II and is associated with the basal transcription-repair factor TFIIH (also called BTF2) resides with MO15, a cyclin-dependent protein kinase that was first found to be involved in cell cycle regulation. Using in vivo and in vitro repair assays, we show that MO15 is important for nucleotide excision repair, most likely through its association with TFIIH, thus providing an unexpected link among three important cellular mechanisms.

Originele taal-2Engels
Pagina's (van-tot)1093-1101
Aantal pagina's9
TijdschriftCell
Volume79
Nummer van het tijdschrift6
DOI's
StatusGepubliceerd - 16 dec. 1994
Extern gepubliceerdJa

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