The occurrence of SDHB gene mutations in pheochromocytoma

Francien H. Van Nederveen, Winand N.M. Dinjens, Esther Korpershoek, Ronald R. De Krijger

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdragepeer review

16 Citaten (Scopus)

Samenvatting

Pheochromocytomas (PCCs) are rare tumors arising from neural crest-derived chromaffin cells. The majority of these tumors are located in the adrenals and gives rise to catecholamine overproduction. In at least 10% of the cases the tumors are located outside the adrenal gland, in extra-adrenal sites like the bladder and the organ of Zuckerkandl. Recent investigations have found mutations in succinate dehydrogenase subunit B (SDHB), the gene coding for subunit B of the respiratory chain complex II. Mutations in the SDHB gene, with additional loss of the wildtype allele, result in loss of function of respiratory complex II and appear to correlate with extra-adrenal location of PCCs. Also, a link has been established between malignant behavior and inactivating mutations of SDHB. In this article we review the published SDHB gene mutations, as well as the location and behavior of the resulting PCCs.

Originele taal-2Engels
TitelPheochromocytoma
SubtitelFirst International Symposium
UitgeverijBlackwell Publishing Inc.
Pagina's177-182
Aantal pagina's6
ISBN van geprinte versie1573315974, 9781573315975
DOI's
StatusGepubliceerd - aug. 2006
Extern gepubliceerdJa

Publicatie series

NaamAnnals of the New York Academy of Sciences
Volume1073
ISSN van geprinte versie0077-8923
ISSN van elektronische versie1749-6632

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