TY - JOUR
T1 - The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB
AU - van der Hout, Annemarie H.
AU - van der Vlies, Pieter
AU - Wijmenga, Cisca
AU - Li, Frederic P.
AU - Oosterhuis, J. Wolter
AU - Buys, Charles H.C.M.
N1 - Funding Information:
This work was supported by a grant from Cancer Foundation. We thank Drs. W. Bradley, jean, A. Driesel, S. Naylor, P. Rabbit@ U. Rapp, making chromosome 3 probes available for this the Netherlands B. Carritt, A. De-and R. White for study.
PY - 1991/11
Y1 - 1991/11
N2 - Cytogenetic studies and DNA analysis have shown that the short arm of chromosome 3 is the region in the genome that is commonly deleted in renal cell carcinoma. By studying loss of heterozygosity in 41 matched tumor/normal kidney tissue pairs, we could delimit the commonly deleted part of 3p to the region between the loci THRB (in 3p24) and D3S2 (in 3p21). The regions on 3p suggested to be involved in the Von Hippel-Lindau syndrome and in hereditary renal cell carcinoma are both outside this smallest region of overlapping deletions. Consequently, renal cell cancer would be an illustration of the possibility that different genes cause the same type of tumor.
AB - Cytogenetic studies and DNA analysis have shown that the short arm of chromosome 3 is the region in the genome that is commonly deleted in renal cell carcinoma. By studying loss of heterozygosity in 41 matched tumor/normal kidney tissue pairs, we could delimit the commonly deleted part of 3p to the region between the loci THRB (in 3p24) and D3S2 (in 3p21). The regions on 3p suggested to be involved in the Von Hippel-Lindau syndrome and in hereditary renal cell carcinoma are both outside this smallest region of overlapping deletions. Consequently, renal cell cancer would be an illustration of the possibility that different genes cause the same type of tumor.
UR - http://www.scopus.com/inward/record.url?scp=0026075496&partnerID=8YFLogxK
U2 - 10.1016/0888-7543(91)90060-R
DO - 10.1016/0888-7543(91)90060-R
M3 - Article
C2 - 1685475
AN - SCOPUS:0026075496
SN - 0888-7543
VL - 11
SP - 537
EP - 542
JO - Genomics
JF - Genomics
IS - 3
ER -