TY - JOUR
T1 - The road to clinical use of high-intensity focused ultrasound for liver cancer
T2 - Technical and clinical consensus
AU - Aubry, Jean Francois
AU - Pauly, Kim Butts
AU - Moonen, Chrit
AU - Haar, Gailter
AU - Ries, Mario
AU - Salomir, Rares
AU - Sokka, Sham
AU - Sekins, Kevin Michael
AU - Shapira, Yerucham
AU - Ye, Fangwei
AU - Huff-Simonin, Heather
AU - Eames, Matt
AU - Hananel, Arik
AU - Kassell, Neal
AU - Napoli, Alessandro
AU - Hwang, Joo Ha
AU - Wu, Feng
AU - Zhang, Lian
AU - Melzer, Andreas
AU - Kim, Young sun
AU - Gedroyc, Wladyslaw M.
N1 - Publisher Copyright:
© 2013 Aubry et al.; licensee BioMed Central Ltd.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Clinical use of high-intensity focused ultrasound (HIFU) under ultrasound or MR guidance as a non-invasive method for treating tumors is rapidly increasing. Tens of thousands of patients have been treated for uterine fibroid, benign prostate hyperplasia, bone metastases, or prostate cancer. Despite the methods' clinical potential, the liver is a particularly challenging organ for HIFU treatment due to the combined effect of respiratory-induced liver motion, partial blocking by the rib cage, and high perfusion/flow. Several technical and clinical solutions have been developed by various groups during the past 15 years to compensate for these problems. A review of current unmet clinical needs is given here, as well as a consensus from a panel of experts about technical and clinical requirements for upcoming pilot and pivotal studies in order to accelerate the development and adoption of focused ultrasound for the treatment of primary and secondary liver cancer.
AB - Clinical use of high-intensity focused ultrasound (HIFU) under ultrasound or MR guidance as a non-invasive method for treating tumors is rapidly increasing. Tens of thousands of patients have been treated for uterine fibroid, benign prostate hyperplasia, bone metastases, or prostate cancer. Despite the methods' clinical potential, the liver is a particularly challenging organ for HIFU treatment due to the combined effect of respiratory-induced liver motion, partial blocking by the rib cage, and high perfusion/flow. Several technical and clinical solutions have been developed by various groups during the past 15 years to compensate for these problems. A review of current unmet clinical needs is given here, as well as a consensus from a panel of experts about technical and clinical requirements for upcoming pilot and pivotal studies in order to accelerate the development and adoption of focused ultrasound for the treatment of primary and secondary liver cancer.
KW - Focused ultrasound
KW - High-intensity ultrasound
KW - Liver cancer
KW - Non-invasive surgery
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85013814494&partnerID=8YFLogxK
U2 - 10.1186/2050-5736-1-13
DO - 10.1186/2050-5736-1-13
M3 - Review article
AN - SCOPUS:85013814494
SN - 2050-5736
VL - 1
JO - Journal of Therapeutic Ultrasound
JF - Journal of Therapeutic Ultrasound
IS - 1
M1 - 13
ER -