TY - JOUR
T1 - The role of isolated limb perfusion for melanoma confined to the extremities
AU - Eggermont, Alexander M.M.
AU - Van Geel, Albertus N.
AU - De Wilt, Johannes H.W.
AU - Ten Hagen, Timo L.M.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Isolated limb perfusion with Melphalan is the best treatment option to control symptomatic multiple small in-transit metastases. When lesions are bulky, Isolated Limb Perfusion (ILP) with Tumor Necrosis Factor (TNF) + Melphalan is superior as in soft tissue sarcoma. TNF changes the pathophysiology, greatly enhances the uptake of Melphalan and destructs selectively the vasculature of large tumors. To date, ILP is not indicated in an adjuvant setting.
AB - Isolated limb perfusion with Melphalan is the best treatment option to control symptomatic multiple small in-transit metastases. When lesions are bulky, Isolated Limb Perfusion (ILP) with Tumor Necrosis Factor (TNF) + Melphalan is superior as in soft tissue sarcoma. TNF changes the pathophysiology, greatly enhances the uptake of Melphalan and destructs selectively the vasculature of large tumors. To date, ILP is not indicated in an adjuvant setting.
UR - http://www.scopus.com/inward/record.url?scp=0037398375&partnerID=8YFLogxK
U2 - 10.1016/S0039-6109(02)00095-6
DO - 10.1016/S0039-6109(02)00095-6
M3 - Review article
C2 - 12744614
AN - SCOPUS:0037398375
SN - 0039-6109
VL - 83
SP - 371
EP - 384
JO - Surgical Clinics of North America
JF - Surgical Clinics of North America
IS - 2
ER -