The role of isolated limb perfusion for melanoma confined to the extremities

Alexander M.M. Eggermont; Albertus N. Van Geel; Johannes H.W. De Wilt; Timo L.M. Ten Hagen

doi:10.1016/S0039-6109(02)00095-6

The role of isolated limb perfusion for melanoma confined to the extremities

Alexander M.M. Eggermont
, Albertus N. Van Geel
, Johannes H.W. De Wilt
, Timo L.M. Ten Hagen

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

21 Citaten (Scopus)

Samenvatting

Isolated limb perfusion with Melphalan is the best treatment option to control symptomatic multiple small in-transit metastases. When lesions are bulky, Isolated Limb Perfusion (ILP) with Tumor Necrosis Factor (TNF) + Melphalan is superior as in soft tissue sarcoma. TNF changes the pathophysiology, greatly enhances the uptake of Melphalan and destructs selectively the vasculature of large tumors. To date, ILP is not indicated in an adjuvant setting.

Originele taal-2	Engels
Pagina's (van-tot)	371-384
Aantal pagina's	14
Tijdschrift	Surgical Clinics of North America
Volume	83
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1016/S0039-6109(02)00095-6
Status	Gepubliceerd - 1 apr 2003
Extern gepubliceerd	Ja

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10.1016/S0039-6109(02)00095-6

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title = "The role of isolated limb perfusion for melanoma confined to the extremities",

abstract = "Isolated limb perfusion with Melphalan is the best treatment option to control symptomatic multiple small in-transit metastases. When lesions are bulky, Isolated Limb Perfusion (ILP) with Tumor Necrosis Factor (TNF) + Melphalan is superior as in soft tissue sarcoma. TNF changes the pathophysiology, greatly enhances the uptake of Melphalan and destructs selectively the vasculature of large tumors. To date, ILP is not indicated in an adjuvant setting.",

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AU - Eggermont, Alexander M.M.

AU - Van Geel, Albertus N.

AU - De Wilt, Johannes H.W.

AU - Ten Hagen, Timo L.M.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Isolated limb perfusion with Melphalan is the best treatment option to control symptomatic multiple small in-transit metastases. When lesions are bulky, Isolated Limb Perfusion (ILP) with Tumor Necrosis Factor (TNF) + Melphalan is superior as in soft tissue sarcoma. TNF changes the pathophysiology, greatly enhances the uptake of Melphalan and destructs selectively the vasculature of large tumors. To date, ILP is not indicated in an adjuvant setting.

AB - Isolated limb perfusion with Melphalan is the best treatment option to control symptomatic multiple small in-transit metastases. When lesions are bulky, Isolated Limb Perfusion (ILP) with Tumor Necrosis Factor (TNF) + Melphalan is superior as in soft tissue sarcoma. TNF changes the pathophysiology, greatly enhances the uptake of Melphalan and destructs selectively the vasculature of large tumors. To date, ILP is not indicated in an adjuvant setting.

UR - https://www.scopus.com/pages/publications/0037398375

U2 - 10.1016/S0039-6109(02)00095-6

DO - 10.1016/S0039-6109(02)00095-6

M3 - Review article

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AN - SCOPUS:0037398375

SN - 0039-6109

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EP - 384

JO - Surgical Clinics of North America

JF - Surgical Clinics of North America

IS - 2

ER -

The role of isolated limb perfusion for melanoma confined to the extremities

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