The role of programmed cell death-1 (PD-1) and its ligands in pediatric cancer

Laura S. van Dam, Verena M. de Zwart, Friederike A.G. Meyer-Wentrup

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

29 Citaten (Scopus)


Programmed cell death-1 (PD-1) and its ligands, PD-L1 and PD-L2 maintain self-tolerance and modulate physiological immune responses. Recently, targeting the PD-1/PD-L1 pathway with blocking antibodies has emerged as a potentially promising approach to treat advanced cancers in adult patients. Since tumor PD-L1 expression is currently considered the most important predictive biomarker for successful checkpoint blockade, we summarize expression data for the most common tumors of childhood. Additionally, we give an introduction into PD-1 function in the immune system to then focus on PD-1 mediated tumor immune escape.

Originele taal-2Engels
Pagina's (van-tot)190-197
Aantal pagina's8
TijdschriftPediatric Blood and Cancer
Nummer van het tijdschrift2
StatusGepubliceerd - 1 feb. 2015
Extern gepubliceerdJa


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