The tractographer’s dilemma: understanding sources of variability in tractography

Flavio Dell’Acqua; Alexander Leemans; Fan Zhang; Francois Rheault; Shawna Farquharson; Alberto De Luca

doi:10.1007/s00429-025-02964-y

The tractographer’s dilemma: understanding sources of variability in tractography

Flavio Dell’Acqua
, Alexander Leemans
, Fan Zhang
, Francois Rheault
, Shawna Farquharson
, Alberto De Luca

Onderzoeksoutput: Bijdrage aan tijdschrift › Brief › peer review

2 Citaten (Scopus)

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Tractography involves many steps, and as such can be heavily affected by data quality, operator decisions such as algorithm and parameter selection and/or biological variables - in addition to random effects such as noise and motion. Due to the interplay between sources of variability, even seemingly minor decisions or overlooked assumptions can lead to major variations in output that can potentially confound tractography results. This article summarizes the main sources of variability in tractography to remind both new and experienced users of the importance of making informed decisions at all stages of the tractography pipeline.

Originele taal-2	Engels
Artikelnummer	99
Tijdschrift	Brain Structure and Function
Volume	230
Nummer van het tijdschrift	6
DOI's	https://doi.org/10.1007/s00429-025-02964-y
Status	Gepubliceerd - 16 jun 2025
Extern gepubliceerd	Ja

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AU - Leemans, Alexander

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AU - Rheault, Francois

AU - Farquharson, Shawna

AU - De Luca, Alberto

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KW - Algorithms

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The tractographer’s dilemma: understanding sources of variability in tractography

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