TY - JOUR
T1 - The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol
AU - on behalf of the International Society of Paediatric Oncology–Renal Tumour Study Group (SIOP–RTSG)
AU - Vujanić, Gordan M.
AU - Gessler, Manfred
AU - Ooms, Ariadne H.A.G.
AU - Collini, Paola
AU - Coulomb-l’Hermine, Aurore
AU - D’Hooghe, Ellen
AU - de Krijger, Ronald R.
AU - Perotti, Daniela
AU - Pritchard-Jones, Kathy
AU - Vokuhl, Christian
AU - van den Heuvel-Eibrink, Marry M.
AU - Graf, Norbert
N1 - Publisher Copyright:
© 2018, Springer Nature Limited.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - On the basis of the results of previous national and international trials and studies, the Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new study protocol for paediatric renal tumours: the UMBRELLA SIOP–RTSG 2016 protocol (the UMBRELLA protocol). Currently, the overall outcomes of patients with Wilms tumour are excellent, but subgroups with poor prognosis and increased relapse rates still exist. The identification of these subgroups is of utmost importance to improve treatment stratification, which might lead to reduction of the direct and late effects of chemotherapy. The UMBRELLA protocol aims to validate new prognostic factors, such as blastemal tumour volume and molecular markers, to further improve outcome. To achieve this aim, large, international, high-quality databases are needed, which dictate optimization and international harmonization of specimen handling and comprehensive sampling of biological material, refine definitions and improve logistics for expert review. To promote broad implementation of the UMBRELLA protocol, the updated SIOP–RTSG pathology and molecular biology protocol for Wilms tumours has been outlined, which is a consensus from the SIOP–RTSG pathology panel.
AB - On the basis of the results of previous national and international trials and studies, the Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new study protocol for paediatric renal tumours: the UMBRELLA SIOP–RTSG 2016 protocol (the UMBRELLA protocol). Currently, the overall outcomes of patients with Wilms tumour are excellent, but subgroups with poor prognosis and increased relapse rates still exist. The identification of these subgroups is of utmost importance to improve treatment stratification, which might lead to reduction of the direct and late effects of chemotherapy. The UMBRELLA protocol aims to validate new prognostic factors, such as blastemal tumour volume and molecular markers, to further improve outcome. To achieve this aim, large, international, high-quality databases are needed, which dictate optimization and international harmonization of specimen handling and comprehensive sampling of biological material, refine definitions and improve logistics for expert review. To promote broad implementation of the UMBRELLA protocol, the updated SIOP–RTSG pathology and molecular biology protocol for Wilms tumours has been outlined, which is a consensus from the SIOP–RTSG pathology panel.
UR - http://www.scopus.com/inward/record.url?scp=85054902421&partnerID=8YFLogxK
U2 - 10.1038/s41585-018-0100-3
DO - 10.1038/s41585-018-0100-3
M3 - Review article
C2 - 30310143
AN - SCOPUS:85054902421
SN - 1759-4812
VL - 15
SP - 693
EP - 701
JO - Nature Reviews Urology
JF - Nature Reviews Urology
IS - 11
ER -