TY - JOUR
T1 - The use of bone age in clinical practice - Part 1
AU - Martin, David D.
AU - Wit, Jan M.
AU - Hochberg, Ze'Ev
AU - Sävendahl, Lars
AU - Van Rijn, Rick R.
AU - Fricke, Oliver
AU - Cameron, Noël
AU - Caliebe, Janina
AU - Hertel, Thomas
AU - Kiepe, Daniela
AU - Albertsson-Wikland, Kerstin
AU - Thodberg, Hans Henrik
AU - Binder, Gerhard
AU - Ranke, Michael B.
PY - 2011/7
Y1 - 2011/7
N2 - This review examines the role of skeletal maturity ('bone age', BA) assessment in clinical practice. BA is mainly used in children with the following conditions: short stature (addressed in part 1 of this review), tall stature, early or late puberty, and congenital adrenal hyperplasia (all addressed in part 2). Various manual and automatic methods of BA assessment have been developed. Healthy tall children tend to have advanced BA and healthy short children tend to have delayed BA in comparison to chronological age. Growth hormone (GH) treatment of children with GH deficiency leads to a catch-up in BA that is usually appropriate for the height of the child. Response to GH is dependent on BA delay in young children with idiopathic short stature, and GH dosage appears to affect BA acceleration. In chronic renal failure, BA is delayed until puberty but then increases due to increased sensitivity of the growth plate to sex steroids, thus further impairing adult height. The assessment of BA provides an important contribution to the diagnostic workup and management of children with short stature.
AB - This review examines the role of skeletal maturity ('bone age', BA) assessment in clinical practice. BA is mainly used in children with the following conditions: short stature (addressed in part 1 of this review), tall stature, early or late puberty, and congenital adrenal hyperplasia (all addressed in part 2). Various manual and automatic methods of BA assessment have been developed. Healthy tall children tend to have advanced BA and healthy short children tend to have delayed BA in comparison to chronological age. Growth hormone (GH) treatment of children with GH deficiency leads to a catch-up in BA that is usually appropriate for the height of the child. Response to GH is dependent on BA delay in young children with idiopathic short stature, and GH dosage appears to affect BA acceleration. In chronic renal failure, BA is delayed until puberty but then increases due to increased sensitivity of the growth plate to sex steroids, thus further impairing adult height. The assessment of BA provides an important contribution to the diagnostic workup and management of children with short stature.
KW - Bone age
KW - Familial short stature
KW - Growth
KW - Growth hormone deficiency
KW - Idiopathic short stature
KW - Skeletal maturity
KW - Small for gestational age
KW - Turner syndrome
UR - http://www.scopus.com/inward/record.url?scp=79960563699&partnerID=8YFLogxK
U2 - 10.1159/000329372
DO - 10.1159/000329372
M3 - Review article
C2 - 21691054
AN - SCOPUS:79960563699
SN - 1663-2818
VL - 76
SP - 1
EP - 9
JO - Hormone Research in Paediatrics
JF - Hormone Research in Paediatrics
IS - 1
ER -