TY - JOUR
T1 - The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction
T2 - A DCCSS-LATER Study
AU - Houtman, Bente M
AU - Walraven, Iris
AU - de Grouw, Elke
AU - van der Maazen, Richard W M
AU - Kremer, Leontien C M
AU - van Dulmen-den Broeder, Eline
AU - van den Heuvel-Eibrink, Marry M
AU - Tissing, Wim J E
AU - Bresters, Dorine
AU - van der Pal, Helena J H
AU - de Vries, Andrica C H
AU - Louwerens, Marloes
AU - van der Heiden-van der Loo, Margriet
AU - Neggers, Sebastian J C
AU - Janssens, Geert O
AU - Blijlevens, Nicole M A
AU - Lambeck, Annechien J A
AU - Preijers, Frank
AU - Loonen, Jacqueline J
N1 - Copyright © 2023 Bente M. Houtman et al.
PY - 2023
Y1 - 2023
N2 - BACKGROUND: Childhood cancer survivors (CCS) who received radiotherapy involving the spleen or total body irradiation (TBI) might be at risk for splenic dysfunction. A comprehensive screening test for examining splenic dysfunction is lacking.OBJECTIVE: We investigated whether IgM memory B-cells could be used to assess splenic dysfunction in CCS who received a splenectomy, radiotherapy involving the spleen, or TBI.METHODS: All CCS were enrolled from the DCCSS-LATER cohort. We analyzed differences in IgM memory B-cells and Howell-Jolly bodies (HJB) in CCS who had a splenectomy (n = 9), received radiotherapy involving the spleen (n = 36), or TBI (n = 15). IgM memory B-cells < 9 cells/µL was defined as abnormal.RESULTS: We observed a higher median number of IgM memory B-cells in CCS who received radiotherapy involving the spleen (31 cells/µL, p=0.06) or TBI (55 cells/µL, p = 0.03) compared to CCS who received splenectomy (20 cells/µL). However, only two CCS had IgM memory B-cells below the lower limit of normal. No difference in IgM memory B-cells was observed between CCS with HJB present and absent (35 cells/µL vs. 44 cells/µL).CONCLUSION: Although the number of IgM memory B-cells differed between splenectomized CCS and CCS who received radiotherapy involving the spleen or TBI, only two CCS showed abnormal values. Therefore, this assessment cannot be used to screen for splenic dysfunction.
AB - BACKGROUND: Childhood cancer survivors (CCS) who received radiotherapy involving the spleen or total body irradiation (TBI) might be at risk for splenic dysfunction. A comprehensive screening test for examining splenic dysfunction is lacking.OBJECTIVE: We investigated whether IgM memory B-cells could be used to assess splenic dysfunction in CCS who received a splenectomy, radiotherapy involving the spleen, or TBI.METHODS: All CCS were enrolled from the DCCSS-LATER cohort. We analyzed differences in IgM memory B-cells and Howell-Jolly bodies (HJB) in CCS who had a splenectomy (n = 9), received radiotherapy involving the spleen (n = 36), or TBI (n = 15). IgM memory B-cells < 9 cells/µL was defined as abnormal.RESULTS: We observed a higher median number of IgM memory B-cells in CCS who received radiotherapy involving the spleen (31 cells/µL, p=0.06) or TBI (55 cells/µL, p = 0.03) compared to CCS who received splenectomy (20 cells/µL). However, only two CCS had IgM memory B-cells below the lower limit of normal. No difference in IgM memory B-cells was observed between CCS with HJB present and absent (35 cells/µL vs. 44 cells/µL).CONCLUSION: Although the number of IgM memory B-cells differed between splenectomized CCS and CCS who received radiotherapy involving the spleen or TBI, only two CCS showed abnormal values. Therefore, this assessment cannot be used to screen for splenic dysfunction.
KW - Humans
KW - Child
KW - Spleen
KW - Cancer Survivors
KW - Neoplasms
KW - Splenectomy/adverse effects
KW - Immunoglobulin M
U2 - 10.1155/2023/5863995
DO - 10.1155/2023/5863995
M3 - Article
C2 - 37901347
SN - 2314-8861
VL - 2023
SP - 5863995
JO - Journal of Immunology Research
JF - Journal of Immunology Research
ER -