The winged-helix transcription factor trident is expressed in actively dividing lymphocytes

Wouter Korver, Jeroen Roose, Anne Wilson, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

22 Citaten (Scopus)

Samenvatting

We recently identified the winged-helix transcription factor Trident and described its expression pattern in synchronized fibroblasts. We have now studied Trident expression in cell lines, differentiating thymocytes and in lymphocytes derived from peripheral blood. During T cell differentiation, expression peaked in the actively dividing immature single positive cells. In peripheral blood lymphocytes, expression of Trident mRNA was absent, but could be induced upon stimulation with mitogens in vitro. These observations imply a function for Trident in dividing lymphocytes.

Originele taal-2Engels
Pagina's (van-tot)157-161
Aantal pagina's5
TijdschriftImmunobiology
Volume198
Nummer van het tijdschrift1-3
DOI's
StatusGepubliceerd - dec. 1997
Extern gepubliceerdJa

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