The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells

Inge Van Der Werf; Catriona Jamieson

doi:10.1016/j.ccell.2019.03.011

The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells

Inge Van Der Werf, Catriona Jamieson

Onderzoeksoutput: Bijdrage aan tijdschrift › Kort overzicht › peer review

20 Citaten (Scopus)

Samenvatting

A prevalent eukaryotic N⁶-methyladensosine (m⁶A) post-transcriptional mark can be “erased” by the m⁶A demethylase FTO, which is commonly deregulated in acute myeloid leukemia (AML). In this issue of Cancer Cell, Huang et al. design small-molecule FTO inhibitors, FB23 and FB23-2, and demonstrate their potent inhibitory impact in AML models.

Originele taal-2	Engels
Pagina's (van-tot)	540-541
Aantal pagina's	2
Tijdschrift	Cancer Cell
Volume	35
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1016/j.ccell.2019.03.011
Status	Gepubliceerd - 15 apr. 2019
Extern gepubliceerd	Ja

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abstract = "A prevalent eukaryotic N6-methyladensosine (m6A) post-transcriptional mark can be “erased” by the m6A demethylase FTO, which is commonly deregulated in acute myeloid leukemia (AML). In this issue of Cancer Cell, Huang et al. design small-molecule FTO inhibitors, FB23 and FB23-2, and demonstrate their potent inhibitory impact in AML models.",

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The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells

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