Therapeutic drug monitoring of voriconazole and posaconazole for invasive aspergillosis.

Seyedmojtaba Seyedmousavi, Johan W. Mouton, Paul E. Verweij, Roger J.M. Brüggemann

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

72 Citaten (Scopus)


Voriconazole and posaconazole are extended-spectrum triazoles recommended for treatment, prophylaxis and salvage therapy of Aspergillus diseases. Over the past decade many papers have emerged supporting the use of therapeutic drug monitoring (TDM) for azole antifungals. TDM is used to tailor the exposure of a specific drug to the individuals to optimize treatment response and minimize side effects. We reviewed the pharmacokinetics and pharmacodynamics (PK-PD) characteristics of voriconazole and posaconazole. We present the available evidence on target concentrations defining maximal efficacy and minimal toxicity. Finally we provide some practical recommendations how to best perform TDM in clinical practice.

Originele taal-2Engels
Pagina's (van-tot)931-941
Aantal pagina's11
TijdschriftExpert Review of Anti-Infective Therapy
Nummer van het tijdschrift9
StatusGepubliceerd - sep. 2013
Extern gepubliceerdJa


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