Therapy of childhood acute myelogenous leukemias

J Vormoor, J Boos, K Stahnke, H Jürgens, J Ritter, U Creutzig

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review


Acute myelogenous leukemia (AML) accounts for approximately 20% of acute leukemias in children. Although AML is more resistant to chemotherapy than acute lymphoblastic leukemia (ALL), significant progress in improving outcome for AML patients has been achieved over the past 15 years. This can be attributed to intensification of chemotherapy, increased use of bone marrow transplantation, and improved supportive care. Thus 30-50% of children with AML achieve long-term event-free survival with current treatment strategies [61, 66, 85, 96]. This review gives an overview about the evolution of and rationale for current pediatric treatment protocols, with special emphasis on the German Berlin-Frankfurt-Münster (BFM) studies, and discusses new directions for the future.

Originele taal-2Engels
Pagina's (van-tot)11-24
Aantal pagina's14
TijdschriftAnnals of hematology
Nummer van het tijdschrift1
StatusGepubliceerd - jul. 1996
Extern gepubliceerdJa


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