TY - JOUR
T1 - To perfuse or not to perfuse? A retrospective comparative study to evaluate the effect of adjuvant isolated regional perfusion in patients with stage I extremity melanoma with a thickness of 1.5 mm or greater
AU - Franklin, H. R.
AU - Schraffordt Koops, H.
AU - Oldhoff, J.
AU - Czarnetzki, B. M.
AU - Macher, E.
AU - Kroon, B. B.R.
AU - Welvaart, K.
AU - Van Der Velden, J. W.
AU - Van Dijk, E.
AU - Van Der Esch, E. P.
AU - Wolter Oosterhuis, J.
AU - Huisman, S. J.
AU - Hart, A. A.M.
AU - Rumke, P.
PY - 1988
Y1 - 1988
N2 - The use of isolated regional perfusion in an adjuvant setting for stage I melanoma of the extremity continues to be controversial. The present retrospective study evaluates the past 20 years' experience by comparing 227 perfused patients from Groningen with 238 matched controls from five hospitals in The Netherlands and Westphalia (a region of West Germany bordering the Netherlands). All patients underwent wide local excision for a primary extremity melanoma of 1.5 mm or greater in thickness. A proportional hazards regression analysis for recurrence of disease and survival identified the significant prognostic factors, of which tumor thickness was the most important. Corrected for these factors, it was not possible to demonstrate a statistically significant effect for perfusion in terms of time to limb recurrence (P = .61), time to regional lymph node metastasis (P = .11), time to distant metastasis (P = .73), disease-free interval (P = .42), and survival (P = .90). No statistically significant differences were seen for adjuvant perfusion in any of the subgroups.
AB - The use of isolated regional perfusion in an adjuvant setting for stage I melanoma of the extremity continues to be controversial. The present retrospective study evaluates the past 20 years' experience by comparing 227 perfused patients from Groningen with 238 matched controls from five hospitals in The Netherlands and Westphalia (a region of West Germany bordering the Netherlands). All patients underwent wide local excision for a primary extremity melanoma of 1.5 mm or greater in thickness. A proportional hazards regression analysis for recurrence of disease and survival identified the significant prognostic factors, of which tumor thickness was the most important. Corrected for these factors, it was not possible to demonstrate a statistically significant effect for perfusion in terms of time to limb recurrence (P = .61), time to regional lymph node metastasis (P = .11), time to distant metastasis (P = .73), disease-free interval (P = .42), and survival (P = .90). No statistically significant differences were seen for adjuvant perfusion in any of the subgroups.
UR - http://www.scopus.com/inward/record.url?scp=0023887408&partnerID=8YFLogxK
U2 - 10.1200/JCO.1988.6.4.701
DO - 10.1200/JCO.1988.6.4.701
M3 - Article
C2 - 3357008
AN - SCOPUS:0023887408
SN - 0732-183X
VL - 6
SP - 701
EP - 708
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 4
ER -