Transcription-coupled repair and premature ageing

J. O. Andressoo, J. H.J. Hoeijmakers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

61 Citaten (Scopus)


During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair. In this review, we will provide a comprehensive overview of cancer and/or accelerated ageing pathologies associated with defects in the multi-step nucleotide excision repair pathway. Moreover, we will discuss evidence suggesting that there is a causative link between transcription-coupled repair and ageing.

Originele taal-2Engels
Pagina's (van-tot)179-194
Aantal pagina's16
TijdschriftMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Nummer van het tijdschrift1-2 SPEC. ISS.
StatusGepubliceerd - 4 sep. 2005
Extern gepubliceerdJa


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