Transcriptional control during T-cell development

Hans Clevers, Pierre Ferrier

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

31 Citaten (Scopus)


During the past few years, the essential role of distinct transcription factors in specifying cell-fate decisions in a stepwise fashion during T-cell differentiation has been revealed. One striking feature is that a single factor can act at several sites throughout T-cell development, possibly through interactions with different partners. The challenge is now to understand how these interactions can account for the co-ordination of complex extracellular signals and gene expression programs, such as those involved in T-cell receptor gene recombination and expression.

Originele taal-2Engels
Pagina's (van-tot)166-171
Aantal pagina's6
TijdschriftCurrent Opinion in Immunology
Nummer van het tijdschrift2
StatusGepubliceerd - apr. 1998
Extern gepubliceerdJa


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