TY - JOUR
T1 - Transcriptional control during T-cell development
AU - Clevers, Hans
AU - Ferrier, Pierre
N1 - Funding Information:
We apologize to those whose valuable contributions to this field were not referenced or were only referenced in the context of a published review, due to space limitations. Work in the Ferrier laboratory is supported by institutional grants from INSERM and CNRS, and by specific grants from the Associationp our la Recherche sur le Cancer, the Ligue Nationale Contre le Cancer, the Minist~re de la Recherche and the Commission of the European Communities.
PY - 1998/4
Y1 - 1998/4
N2 - During the past few years, the essential role of distinct transcription factors in specifying cell-fate decisions in a stepwise fashion during T-cell differentiation has been revealed. One striking feature is that a single factor can act at several sites throughout T-cell development, possibly through interactions with different partners. The challenge is now to understand how these interactions can account for the co-ordination of complex extracellular signals and gene expression programs, such as those involved in T-cell receptor gene recombination and expression.
AB - During the past few years, the essential role of distinct transcription factors in specifying cell-fate decisions in a stepwise fashion during T-cell differentiation has been revealed. One striking feature is that a single factor can act at several sites throughout T-cell development, possibly through interactions with different partners. The challenge is now to understand how these interactions can account for the co-ordination of complex extracellular signals and gene expression programs, such as those involved in T-cell receptor gene recombination and expression.
UR - http://www.scopus.com/inward/record.url?scp=0031968028&partnerID=8YFLogxK
U2 - 10.1016/S0952-7915(98)80245-8
DO - 10.1016/S0952-7915(98)80245-8
M3 - Article
C2 - 9602305
AN - SCOPUS:0031968028
SN - 0952-7915
VL - 10
SP - 166
EP - 171
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 2
ER -