Transmaternal cell flow leads to antigen-experienced cord blood

Miranda P. Dierselhuis, Els C. Blokland, Jos Pool, Ellen Schrama, Sicco A. Scherjon, Els Goulmy

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

22 Citaten (Scopus)


Umbilical cord blood (UCB) is used for HSCT. It is known that UCB can comprise Ag-specific T cells. Here we question whether solely transmaternal cell flow may immunize UCB. Twenty-three female UCB samples were collected from healthy mothers and analyzed for minor histocompatibility Ag HY-specific responses. Forty-two of 104 tetramerpos T-cell clones, isolated from 16 of 17 UCB samples, showed male-specific lysis in vitro. Male microchimerism was present in 6 of 12 UCB samples analyzed. In conclusion, female UCB comprises HY-specific cytotoxic T cells. The immunization is presumably caused by transmaternal cell flow of male microchimerism present in the mother. The presence of immune cells in UCB that are not directed against maternal foreign Ags is remarkable and may explain the reported clinical observation of improved HSCT outcome with younger sibling donors.

Originele taal-2Engels
Pagina's (van-tot)505-510
Aantal pagina's6
Nummer van het tijdschrift3
StatusGepubliceerd - 19 jul. 2012
Extern gepubliceerdJa


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