Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients

Yvette A.H. Matser, Matty L. Terpstra, Silvio Nadalin, George D. Nossent, Jan de Boer, Barbara C. van Bemmel, Susanne van Eeden, Klemens Budde, Susanne Brakemeier, Frederike J. Bemelman

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

24 Citaten (Scopus)

Samenvatting

We report 4 cases of breast cancer transmission to transplant recipients from a single organ donor that occurred years after donation. The diagnosis of breast cancer was occult at the time of donation. All of the recipients developed a histologically similar type of breast cancer within 16 months to 6 years after transplantation. Three out of 4 recipients died as a result of widely metastasized disease. One of the recipients survived after transplant nephrectomy followed by cessation of immunosuppression and chemotherapy. This extraordinary case points out the often fatal consequences of donor-derived breast cancer and suggests that removal of the donor organ and restoration of immunity can induce complete remission.

Originele taal-2Engels
Pagina's (van-tot)1810-1814
Aantal pagina's5
TijdschriftAmerican Journal of Transplantation
Volume18
Nummer van het tijdschrift7
DOI's
StatusGepubliceerd - jul. 2018
Extern gepubliceerdJa

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