Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients

Yvette A.H. Matser; Matty L. Terpstra; Silvio Nadalin; George D. Nossent; Jan de Boer; Barbara C. van Bemmel; Susanne van Eeden; Klemens Budde; Susanne Brakemeier; Frederike J. Bemelman

doi:10.1111/ajt.14766

Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients

Yvette A.H. Matser, Matty L. Terpstra, Silvio Nadalin, George D. Nossent, Jan de Boer, Barbara C. van Bemmel, Susanne van Eeden, Klemens Budde, Susanne Brakemeier, Frederike J. Bemelman

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

35 Citaten (Scopus)

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We report 4 cases of breast cancer transmission to transplant recipients from a single organ donor that occurred years after donation. The diagnosis of breast cancer was occult at the time of donation. All of the recipients developed a histologically similar type of breast cancer within 16 months to 6 years after transplantation. Three out of 4 recipients died as a result of widely metastasized disease. One of the recipients survived after transplant nephrectomy followed by cessation of immunosuppression and chemotherapy. This extraordinary case points out the often fatal consequences of donor-derived breast cancer and suggests that removal of the donor organ and restoration of immunity can induce complete remission.

Originele taal-2	Engels
Pagina's (van-tot)	1810-1814
Aantal pagina's	5
Tijdschrift	American Journal of Transplantation
Volume	18
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.1111/ajt.14766
Status	Gepubliceerd - jul. 2018
Extern gepubliceerd	Ja

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10.1111/ajt.14766

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title = "Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients",

abstract = "We report 4 cases of breast cancer transmission to transplant recipients from a single organ donor that occurred years after donation. The diagnosis of breast cancer was occult at the time of donation. All of the recipients developed a histologically similar type of breast cancer within 16 months to 6 years after transplantation. Three out of 4 recipients died as a result of widely metastasized disease. One of the recipients survived after transplant nephrectomy followed by cessation of immunosuppression and chemotherapy. This extraordinary case points out the often fatal consequences of donor-derived breast cancer and suggests that removal of the donor organ and restoration of immunity can induce complete remission.",

keywords = "clinical decision-making, clinical research/practice, complication: malignant, donors and donation: deceased, organ transplantation in general",

author = "Matser, {Yvette A.H.} and Terpstra, {Matty L.} and Silvio Nadalin and Nossent, {George D.} and {de Boer}, Jan and {van Bemmel}, {Barbara C.} and {van Eeden}, Susanne and Klemens Budde and Susanne Brakemeier and Bemelman, {Frederike J.}",

note = "Publisher Copyright: {\textcopyright} 2018 The American Society of Transplantation and the American Society of Transplant Surgeons",

year = "2018",

month = jul,

doi = "10.1111/ajt.14766",

language = "English",

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AU - Matser, Yvette A.H.

AU - Terpstra, Matty L.

AU - Nadalin, Silvio

AU - Nossent, George D.

AU - de Boer, Jan

AU - van Bemmel, Barbara C.

AU - van Eeden, Susanne

AU - Budde, Klemens

AU - Brakemeier, Susanne

AU - Bemelman, Frederike J.

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N2 - We report 4 cases of breast cancer transmission to transplant recipients from a single organ donor that occurred years after donation. The diagnosis of breast cancer was occult at the time of donation. All of the recipients developed a histologically similar type of breast cancer within 16 months to 6 years after transplantation. Three out of 4 recipients died as a result of widely metastasized disease. One of the recipients survived after transplant nephrectomy followed by cessation of immunosuppression and chemotherapy. This extraordinary case points out the often fatal consequences of donor-derived breast cancer and suggests that removal of the donor organ and restoration of immunity can induce complete remission.

AB - We report 4 cases of breast cancer transmission to transplant recipients from a single organ donor that occurred years after donation. The diagnosis of breast cancer was occult at the time of donation. All of the recipients developed a histologically similar type of breast cancer within 16 months to 6 years after transplantation. Three out of 4 recipients died as a result of widely metastasized disease. One of the recipients survived after transplant nephrectomy followed by cessation of immunosuppression and chemotherapy. This extraordinary case points out the often fatal consequences of donor-derived breast cancer and suggests that removal of the donor organ and restoration of immunity can induce complete remission.

KW - clinical decision-making

KW - clinical research/practice

KW - complication: malignant

KW - donors and donation: deceased

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Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients

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