Treatment of colon cancer in rats with rMuTNF and the interferon-inducer bropirimine

R. L. Marquet, R. W.F. de Bruin, A. M.M. Eggermont, J. Jeekel

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

2 Citaten (Scopus)

Samenvatting

It is well documented that the antitumor activity of tumor necrosis factor (TNF) is improved by interferons (IFN's). Bropirimine (BP) is an immune response modifier which induces IFN. Both TNF and BP have the capacity to inhibit the growth of a transplantable colon tumor (CC 531) in inbred WAG rats. In the present study their combined use was investigated in a one-week assay, with the tumor implanted under the renal capsule. The results indicate that BP, given on days 0 and 1, and 1 μg TNF on days 0, 2 and 4 act additively, leading to an almost complete inhibition of tumor growth.

Originele taal-2Engels
Pagina's (van-tot)151-152
Aantal pagina's2
TijdschriftAgents and Actions
Volume26
Nummer van het tijdschrift1-2
DOI's
StatusGepubliceerd - jan. 1989
Extern gepubliceerdJa

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