TY - JOUR
T1 - Trends in treatment and survival for advanced laryngeal cancer
T2 - A 20-year population-based study in the Netherlands
AU - Timmermans, Adriana J.
AU - Van Dijk, Boukje A.C.
AU - Overbeek, Lucy I.H.
AU - Van Velthuysen, Marie Louise F.
AU - Van Tinteren, Harm
AU - Hilgers, Frans J.M.
AU - Van Den Brekel, Michiel W.M.
N1 - Publisher Copyright:
© 2015 Wiley Periodicals, Inc..
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Background The purpose of this study was to determine time trends for primary treatment modalities in advanced laryngeal cancer, overall survival (OS), and laryngectomy-free interval (LFI) over the last 2 decades in The Netherlands. Methods We conducted an analysis of T3 to T4 laryngeal cancer data from 2 combined national (population-based and pathology-based) cancer registries. Results A total of 2072 T3 cases (14.7%) and 1722 T4 cases (12.2%) were identified. Total laryngectomy as primary treatment modality decreased, whereas radiotherapy (RT) increased. For T3 disease, 5-year OS after primary total laryngectomy (+/- adjuvant RT), RT, and chemoradiotherapy (CRT) was 49%, 47%, and 45%, respectively. For T4 disease, this was 48%, 34%, and 42% (overall p <.0001), respectively. Five-year LFI for T3 disease was 81% (RT) and 77% (CRT), and for T4 disease it was 81% and 87%, respectively. Conclusion From 1991 to 2010 total laryngectomy as primary treatment modality for advanced laryngeal cancer decreased and RT increased. T3 disease showed similar survival rates for all primary treatment modalities. For T4 disease, total laryngectomy (+ adjuvant RT) showed the best survival.
AB - Background The purpose of this study was to determine time trends for primary treatment modalities in advanced laryngeal cancer, overall survival (OS), and laryngectomy-free interval (LFI) over the last 2 decades in The Netherlands. Methods We conducted an analysis of T3 to T4 laryngeal cancer data from 2 combined national (population-based and pathology-based) cancer registries. Results A total of 2072 T3 cases (14.7%) and 1722 T4 cases (12.2%) were identified. Total laryngectomy as primary treatment modality decreased, whereas radiotherapy (RT) increased. For T3 disease, 5-year OS after primary total laryngectomy (+/- adjuvant RT), RT, and chemoradiotherapy (CRT) was 49%, 47%, and 45%, respectively. For T4 disease, this was 48%, 34%, and 42% (overall p <.0001), respectively. Five-year LFI for T3 disease was 81% (RT) and 77% (CRT), and for T4 disease it was 81% and 87%, respectively. Conclusion From 1991 to 2010 total laryngectomy as primary treatment modality for advanced laryngeal cancer decreased and RT increased. T3 disease showed similar survival rates for all primary treatment modalities. For T4 disease, total laryngectomy (+ adjuvant RT) showed the best survival.
KW - laryngeal cancer
KW - radiotherapy
KW - survival
KW - total laryngectomy
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=84940498776&partnerID=8YFLogxK
U2 - 10.1002/hed.24200
DO - 10.1002/hed.24200
M3 - Article
C2 - 26315454
AN - SCOPUS:84940498776
SN - 1043-3074
VL - 38
SP - E1247-E1255
JO - Head and Neck
JF - Head and Neck
ER -