Samenvatting
The aetiology of pre-eclampsia is thought to originate from aberrant spiral artery remodelling and invasion evoking cellular oxidative stress. Previously, we discovered differentially expressed proteins in trophoblast cells of pre-eclamptic pregnancies. One of these proteins is calcyclin (S100A6); a Ca2+-binding protein associated with cellular stress response. By immunohistochemistry on formalin-fixed paraffin-embedded placental tissue, calcyclin expression was compared between women with early pre-eclampsia (n = 72) and non-hypertensive control patients (n = 66) (χ2, p = 0.006) blindly by two observers. Significantly more intense staining was seen in trophoblast cells of pre-eclamptic pregnancies compared to control placentas suggesting that trophoblast calcyclin is elevated in early pregnancy .
Originele taal-2 | Engels |
---|---|
Pagina's (van-tot) | 7-10 |
Aantal pagina's | 4 |
Tijdschrift | Pregnancy Hypertension |
Volume | 4 |
Nummer van het tijdschrift | 1 |
DOI's | |
Status | Gepubliceerd - jan. 2014 |
Extern gepubliceerd | Ja |