Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia

P. B.B. Schol; C. Güzel; E. A.P. Steegers; R. R. De Krijger; T. M. Luider

doi:10.1016/j.preghy.2013.11.003

Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia

P. B.B. Schol, C. Güzel, E. A.P. Steegers, R. R. De Krijger, T. M. Luider

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

6 Citaten (Scopus)

Samenvatting

The aetiology of pre-eclampsia is thought to originate from aberrant spiral artery remodelling and invasion evoking cellular oxidative stress. Previously, we discovered differentially expressed proteins in trophoblast cells of pre-eclamptic pregnancies. One of these proteins is calcyclin (S100A6); a Ca²⁺-binding protein associated with cellular stress response. By immunohistochemistry on formalin-fixed paraffin-embedded placental tissue, calcyclin expression was compared between women with early pre-eclampsia (n = 72) and non-hypertensive control patients (n = 66) (χ², p = 0.006) blindly by two observers. Significantly more intense staining was seen in trophoblast cells of pre-eclamptic pregnancies compared to control placentas suggesting that trophoblast calcyclin is elevated in early pregnancy .

Originele taal-2	Engels
Pagina's (van-tot)	7-10
Aantal pagina's	4
Tijdschrift	Pregnancy Hypertension
Volume	4
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.preghy.2013.11.003
Status	Gepubliceerd - jan. 2014
Extern gepubliceerd	Ja

Toegang tot document

10.1016/j.preghy.2013.11.003

Citeer dit

@article{ae1102ba25114f2d9ee70025890099f7,

title = "Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia",

abstract = "The aetiology of pre-eclampsia is thought to originate from aberrant spiral artery remodelling and invasion evoking cellular oxidative stress. Previously, we discovered differentially expressed proteins in trophoblast cells of pre-eclamptic pregnancies. One of these proteins is calcyclin (S100A6); a Ca2+-binding protein associated with cellular stress response. By immunohistochemistry on formalin-fixed paraffin-embedded placental tissue, calcyclin expression was compared between women with early pre-eclampsia (n = 72) and non-hypertensive control patients (n = 66) (χ2, p = 0.006) blindly by two observers. Significantly more intense staining was seen in trophoblast cells of pre-eclamptic pregnancies compared to control placentas suggesting that trophoblast calcyclin is elevated in early pregnancy .",

keywords = "Calcyclin, Pre-eclampsia, S100A6, Trophoblast",

author = "Schol, {P. B.B.} and C. G{\"u}zel and Steegers, {E. A.P.} and {De Krijger}, {R. R.} and Luider, {T. M.}",

year = "2014",

month = jan,

doi = "10.1016/j.preghy.2013.11.003",

language = "English",

volume = "4",

pages = "7--10",

journal = "Pregnancy Hypertension",

issn = "2210-7789",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia

AU - Schol, P. B.B.

AU - Güzel, C.

AU - Steegers, E. A.P.

AU - De Krijger, R. R.

AU - Luider, T. M.

PY - 2014/1

Y1 - 2014/1

N2 - The aetiology of pre-eclampsia is thought to originate from aberrant spiral artery remodelling and invasion evoking cellular oxidative stress. Previously, we discovered differentially expressed proteins in trophoblast cells of pre-eclamptic pregnancies. One of these proteins is calcyclin (S100A6); a Ca2+-binding protein associated with cellular stress response. By immunohistochemistry on formalin-fixed paraffin-embedded placental tissue, calcyclin expression was compared between women with early pre-eclampsia (n = 72) and non-hypertensive control patients (n = 66) (χ2, p = 0.006) blindly by two observers. Significantly more intense staining was seen in trophoblast cells of pre-eclamptic pregnancies compared to control placentas suggesting that trophoblast calcyclin is elevated in early pregnancy .

AB - The aetiology of pre-eclampsia is thought to originate from aberrant spiral artery remodelling and invasion evoking cellular oxidative stress. Previously, we discovered differentially expressed proteins in trophoblast cells of pre-eclamptic pregnancies. One of these proteins is calcyclin (S100A6); a Ca2+-binding protein associated with cellular stress response. By immunohistochemistry on formalin-fixed paraffin-embedded placental tissue, calcyclin expression was compared between women with early pre-eclampsia (n = 72) and non-hypertensive control patients (n = 66) (χ2, p = 0.006) blindly by two observers. Significantly more intense staining was seen in trophoblast cells of pre-eclamptic pregnancies compared to control placentas suggesting that trophoblast calcyclin is elevated in early pregnancy .

KW - Calcyclin

KW - Pre-eclampsia

KW - S100A6

KW - Trophoblast

UR - http://www.scopus.com/inward/record.url?scp=84894375204&partnerID=8YFLogxK

U2 - 10.1016/j.preghy.2013.11.003

DO - 10.1016/j.preghy.2013.11.003

M3 - Article

AN - SCOPUS:84894375204

SN - 2210-7789

VL - 4

SP - 7

EP - 10

JO - Pregnancy Hypertension

JF - Pregnancy Hypertension

IS - 1

ER -

Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit