Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia

P. B.B. Schol; C. Güzel; E. A.P. Steegers; R. R. De Krijger; T. M. Luider

doi:10.1016/j.preghy.2013.11.003

Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia

P. B.B. Schol, C. Güzel, E. A.P. Steegers, R. R. De Krijger, T. M. Luider

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

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The aetiology of pre-eclampsia is thought to originate from aberrant spiral artery remodelling and invasion evoking cellular oxidative stress. Previously, we discovered differentially expressed proteins in trophoblast cells of pre-eclamptic pregnancies. One of these proteins is calcyclin (S100A6); a Ca²⁺-binding protein associated with cellular stress response. By immunohistochemistry on formalin-fixed paraffin-embedded placental tissue, calcyclin expression was compared between women with early pre-eclampsia (n = 72) and non-hypertensive control patients (n = 66) (χ², p = 0.006) blindly by two observers. Significantly more intense staining was seen in trophoblast cells of pre-eclamptic pregnancies compared to control placentas suggesting that trophoblast calcyclin is elevated in early pregnancy .

Originele taal-2	Engels
Pagina's (van-tot)	7-10
Aantal pagina's	4
Tijdschrift	Pregnancy Hypertension
Volume	4
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.preghy.2013.11.003
Status	Gepubliceerd - jan. 2014
Extern gepubliceerd	Ja

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AU - Steegers, E. A.P.

AU - De Krijger, R. R.

AU - Luider, T. M.

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Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia

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