TY - JOUR
T1 - Tumor environment
T2 - A potent driving force in colorectal cancer?
AU - Barker, Nick
AU - Clevers, Hans
PY - 2001
Y1 - 2001
N2 - Current models predict that colorectal carcinogenesis proceeds primarily through the progressive accumulation of fixed genetic changes in key tumor suppressor genes, oncogenes and DNA repair components. However, recent studies found evidence of dynamic changes in cellular adhesion and β-catenin localization occurring during invasion, metastasis and expansion of well-differentiated colorectal cancers. It is proposed that such changes might be driven by the local tumor environment, which, if validated, would necessitate a revision of the current linear tumor progression model.
AB - Current models predict that colorectal carcinogenesis proceeds primarily through the progressive accumulation of fixed genetic changes in key tumor suppressor genes, oncogenes and DNA repair components. However, recent studies found evidence of dynamic changes in cellular adhesion and β-catenin localization occurring during invasion, metastasis and expansion of well-differentiated colorectal cancers. It is proposed that such changes might be driven by the local tumor environment, which, if validated, would necessitate a revision of the current linear tumor progression model.
UR - http://www.scopus.com/inward/record.url?scp=0035194206&partnerID=8YFLogxK
U2 - 10.1016/S1471-4914(01)02215-8
DO - 10.1016/S1471-4914(01)02215-8
M3 - Review article
C2 - 11733201
AN - SCOPUS:0035194206
SN - 1471-4914
VL - 7
SP - 535
EP - 537
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 12
ER -