Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

J. H.W. De Wilt, T. L.M. Ten Hagen, G. De Boeck, S. T. Van Tiel, E. A. De Bruijn, A. M.M. Eggermont

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

175 Citaten (Scopus)

Samenvatting

Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.

Originele taal-2Engels
Pagina's (van-tot)1000-1003
Aantal pagina's4
TijdschriftBritish Journal of Cancer
Volume82
Nummer van het tijdschrift5
DOI's
StatusGepubliceerd - 2000
Extern gepubliceerdJa

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