TY - JOUR
T1 - Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions
AU - Ariazi, Jennifer
AU - Benowitz, Andrew
AU - De Biasi, Vern
AU - Den Boer, Monique L
AU - Cherqui, Stephanie
AU - Cui, Haifeng
AU - Douillet, Nathalie
AU - Eugenin, Eliseo A
AU - Favre, David
AU - Goodman, Spencer
AU - Gousset, Karine
AU - Hanein, Dorit
AU - Israel, David I
AU - Kimura, Shunsuke
AU - Kirkpatrick, Robert B
AU - Kuhn, Nastaran
AU - Jeong, Claire
AU - Lou, Emil
AU - Mailliard, Robbie
AU - Maio, Stephen
AU - Okafo, George
AU - Osswald, Matthias
AU - Pasquier, Jennifer
AU - Polak, Roel
AU - Pradel, Gabriele
AU - de Rooij, Bob
AU - Schaeffer, Peter
AU - Skeberdis, Vytenis A
AU - Smith, Ian F
AU - Tanveer, Ahmad
AU - Volkmann, Niels
AU - Wu, Zhenhua
AU - Zurzolo, Chiara
N1 - Publisher Copyright:
© 2017 Ariazi, Benowitz, De Biasi, Den Boer, Cherqui, Cui, Douillet, Eugenin, Favre, Goodman, Gousset, Hanein, Israel, Kimura, Kirkpatrick, Kuhn, Jeong, Lou, Mailliard, Maio, Okafo, Osswald, Pasquier, Polak, Pradel, de Rooij, Schaeffer, Skeberdis, Smith, Tanveer, Volkmann, Wu and Zurzolo.
PY - 2017
Y1 - 2017
N2 - Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells. The proposed functions of TNTs are diverse and not well understood but have been shown to include the cell-to-cell transfer of vesicles, organelles, electrical stimuli and small molecules. However, the exact role of TNTs and gap junctions for intercellular communication and their impact on disease is still uncertain and thus, the subject of much debate. The combined data from numerous laboratories indicate that some TNT mediate a long-range gap junctional communication to coordinate metabolism and signaling, in relation to infectious, genetic, metabolic, cancer, and age-related diseases. This review aims to describe the current knowledge, challenges and future perspectives to characterize and explore this new intercellular communication system and to design TNT-based therapeutic strategies.
AB - Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells. The proposed functions of TNTs are diverse and not well understood but have been shown to include the cell-to-cell transfer of vesicles, organelles, electrical stimuli and small molecules. However, the exact role of TNTs and gap junctions for intercellular communication and their impact on disease is still uncertain and thus, the subject of much debate. The combined data from numerous laboratories indicate that some TNT mediate a long-range gap junctional communication to coordinate metabolism and signaling, in relation to infectious, genetic, metabolic, cancer, and age-related diseases. This review aims to describe the current knowledge, challenges and future perspectives to characterize and explore this new intercellular communication system and to design TNT-based therapeutic strategies.
KW - Alzheimer
KW - Cancer
KW - Gap junctions
KW - Inflammation
KW - Reactivation
UR - http://www.scopus.com/inward/record.url?scp=85032279216&partnerID=8YFLogxK
U2 - 10.3389/fnmol.2017.00333
DO - 10.3389/fnmol.2017.00333
M3 - Review article
C2 - 29089870
SN - 1662-5099
VL - 10
SP - 333
JO - Frontiers in molecular neuroscience
JF - Frontiers in molecular neuroscience
M1 - 333
ER -