Update on the Pathophysiology and Risk Factors for the Development of Malignant Testicular Germ Cell Tumors in Complete Androgen Insensitivity Syndrome

Martine Cools, Leendert Looijenga

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Samenvatting

Prophylactic gonadectomy in young adult women with complete androgen insensitivity syndrome (CAIS) to avoid development of an invasive testicular germ cell tumor (TGCT) is currently advised in most centers. However, women with CAIS increasingly question the need of this procedure. In order to provide optimal counseling and follow-up of these women, insight in the mechanisms underlying TGCT development in androgen insensitivity syndrome (AIS), data regarding the incidence of TGCT in AIS adults specifically, and an overview of existing and novel screening tools for in situ and invasive neoplastic lesions are crucial. The current knowledge regarding these topics is revised in this paper.

Originele taal-2Engels
Pagina's (van-tot)175-181
Aantal pagina's7
TijdschriftSexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation
Volume11
Nummer van het tijdschrift4
DOI's
StatusGepubliceerd - 2017
Extern gepubliceerdJa

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