Samenvatting
The capacity of the 3D-organoid cultures to resemble a near-physiological tissue organization and to mimic - to a certain degree - organ functionality, make organoids an excellent model for applications spanning from basic developmental/stem cell research to personalized medicine. Here, we review key findings achieved through organoid technology, and we discuss applications such as disease - and tumour modelling, correction of genetic mutations and understanding gene - and cell functions. Finally, we discuss future developments in the field.
Originele taal-2 | Engels |
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Pagina's (van-tot) | R99-R107 |
Tijdschrift | Human molecular genetics |
Volume | 27 |
Nummer van het tijdschrift | R2 |
DOI's | |
Status | Gepubliceerd - 1 aug. 2018 |
Extern gepubliceerd | Ja |