Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

Keyphrases

• Mutational Signatures 100%
• In Cancer 100%
• Stem Cell Organoids 100%
• NTHL1 100%
• Human Stem Cells 100%
• CRISPR Activation 100%
• Mutational Processes 50%
• Whole Genome Sequencing 50%
• Cancer Etiology 50%
• MLH1 50%
• Subclone 50%
• Mismatch Repair Genes 50%
• Cancer Predisposition Genes 50%
• Breast Cancer 50%
• Mismatch Repair 50%
• Base Excision Repair 50%
• Organoids 50%
• Colorectal Cancer 50%
• Prognostic Value 50%
• Repair Proteins 50%
• Cancer Initiation 50%
• Diagnostic Value 50%
• DNA Repair Genes 50%
• Replication Error 50%
• Colonoids 50%
• Cancer Genome 50%
• Cancer Progression 50%
• Mutation Accumulation 50%
• Human Colon 50%
• CRISPR-Cas9 System 50%
• Germline 50%
• Cancer-associated 50%
• Cancer Origin 50%
• Accurately Model 50%
• Model Errors 50%
• Mutation Profile 50%

Biochemistry, Genetics and Molecular Biology

• DNA Mismatch Repair 100%
• CRISPR 100%
• Stem Cell 100%
• Whole Genome Sequencing 50%
• Germline 50%
• MLH1 50%
• Germ Cell 50%
• CRISPR/Cas9 50%
• Base Excision Repair 50%
• Mutation Accumulation 50%
• Subcloning 50%
• DNA Repair 50%
• Colon 50%