TY - JOUR
T1 - Validity of simplified 3′-Deoxy-3′-[18F] fluorothymidine uptake measures for monitoring response to chemotherapy in locally advanced breast cancer
AU - Lubberink, Mark
AU - Direcks, Wieteke
AU - Emmering, Jasper
AU - Van Tinteren, Harm
AU - Hoekstra, Otto S.
AU - Van Der Hoeven, Jacobus J.
AU - Molthoff, Carla F.M.
AU - Lammertsma, Adriaan A.
N1 - Funding Information:
Acknowledgements. The authors would like to thank Suzette van Balen and Rob Koopmans for scanning and image reconstruction, Martien Mooijer and Pieter Klein for tracer synthesis and Henri Greuter for blood measurements. Financial support was provided by the Dutch Cancer Society (VU 2003-2822) and the Susan G. Komen Breast Cancer Foundation (#IMG0402756).
PY - 2012/12
Y1 - 2012/12
N2 - Purpose: Positron emission tomography using 3′-deoxy-3′-[ 18F]fluorothymidine ([18F]FLT) has been suggested as a means for monitoring response to chemotherapy. The aim of this study was to evaluate the validity of simplified uptake measures for assessing response to chemotherapy using [18F]FLT in locally advanced breast cancer (LABC). Procedures: Fifteen LABC patients underwent dynamic [18F]FLT scans both prior to and after the first cycle of chemotherapy with fluorouracil, epirubicin or doxorubicin, and cyclophosphamide. The net uptake rate constant of [18F]FLT, Ki, determined by non-linear regression (NLR) of an irreversible two-tissue compartment model was used as the gold standard. In addition to Patlak graphical analysis, standardised uptake values (SUV) and tumour-to-whole blood ratio (TBR) were used for analysing [18F]FLT data. Correlations and relationships between simplified uptake measures and NLR before and after chemotherapy were assessed using regression analysis. Results: No significant differences in both pre- and post-chemotherapy relationships between any of the simplified uptake measures and NLR were found. However, changes in SUV between baseline and post-therapy scans showed a significant negative bias and slope less than one, while TBR did not. Conclusions: In LABC, TBR instead of SUV may be preferred for monitoring response to chemotherapy with [18F]FLT.
AB - Purpose: Positron emission tomography using 3′-deoxy-3′-[ 18F]fluorothymidine ([18F]FLT) has been suggested as a means for monitoring response to chemotherapy. The aim of this study was to evaluate the validity of simplified uptake measures for assessing response to chemotherapy using [18F]FLT in locally advanced breast cancer (LABC). Procedures: Fifteen LABC patients underwent dynamic [18F]FLT scans both prior to and after the first cycle of chemotherapy with fluorouracil, epirubicin or doxorubicin, and cyclophosphamide. The net uptake rate constant of [18F]FLT, Ki, determined by non-linear regression (NLR) of an irreversible two-tissue compartment model was used as the gold standard. In addition to Patlak graphical analysis, standardised uptake values (SUV) and tumour-to-whole blood ratio (TBR) were used for analysing [18F]FLT data. Correlations and relationships between simplified uptake measures and NLR before and after chemotherapy were assessed using regression analysis. Results: No significant differences in both pre- and post-chemotherapy relationships between any of the simplified uptake measures and NLR were found. However, changes in SUV between baseline and post-therapy scans showed a significant negative bias and slope less than one, while TBR did not. Conclusions: In LABC, TBR instead of SUV may be preferred for monitoring response to chemotherapy with [18F]FLT.
KW - FLT
KW - Modelling
KW - PET
KW - Response monitoring
KW - SUV
UR - https://www.scopus.com/pages/publications/84870461025
U2 - 10.1007/s11307-012-0547-1
DO - 10.1007/s11307-012-0547-1
M3 - Article
C2 - 22392642
AN - SCOPUS:84870461025
SN - 1536-1632
VL - 14
SP - 777
EP - 782
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
IS - 6
ER -