TY - JOUR
T1 - Value of the Sentinel Node Procedure in Pediatric Extremity Rhabdomyosarcoma
T2 - A Systematic Review and Retrospective Cohort Study
AU - Jeremiasse, Bernadette
AU - van der Steeg, Alida F W
AU - Fiocco, Marta
AU - Hobbelink, Monique G G
AU - Merks, Johannes H M
AU - Godzinski, Jan
AU - Shulkin, Barry L
AU - Wijnen, Marc H W A
AU - Terwisscha van Scheltinga, Cecilia E J
N1 - © 2021. The Author(s).
PY - 2021/5
Y1 - 2021/5
N2 - BACKGROUND: Our aim is to show whether the sentinel node procedure (SNP) is recommendable for pediatric patients with extremity rhabdomyosarcoma (RMS). Lymph node metastases are an important prognostic factor in pediatric patients with extremity RMS. Accurate nodal staging is necessary to treat the patient accordingly. An alternative to the current recommended lymph node sampling is the sentinel node procedure (SNP).METHODS: A systematic review was performed summarizing all published cases of SNP in addition to 13 cases from our hospital and 8 cases from two other hospitals that have not been published before.RESULTS: For all patients (n = 55), at least one SLN was identified, but the SNP technique used was not uniform. The SNP changed the nodal classification of eight patients (17.0%) and had a false-negative rate of 10.5%.CONCLUSIONS: The SNP is recommendable for pediatric patients with extremity RMS. It can change lymph node status and can be used to sample patients in a more targeted way than nodal sampling alone. Therefore, we recommend use of the SNP in addition to clinical and radiological nodal assessment for pediatric patients with extremity RMS.
AB - BACKGROUND: Our aim is to show whether the sentinel node procedure (SNP) is recommendable for pediatric patients with extremity rhabdomyosarcoma (RMS). Lymph node metastases are an important prognostic factor in pediatric patients with extremity RMS. Accurate nodal staging is necessary to treat the patient accordingly. An alternative to the current recommended lymph node sampling is the sentinel node procedure (SNP).METHODS: A systematic review was performed summarizing all published cases of SNP in addition to 13 cases from our hospital and 8 cases from two other hospitals that have not been published before.RESULTS: For all patients (n = 55), at least one SLN was identified, but the SNP technique used was not uniform. The SNP changed the nodal classification of eight patients (17.0%) and had a false-negative rate of 10.5%.CONCLUSIONS: The SNP is recommendable for pediatric patients with extremity RMS. It can change lymph node status and can be used to sample patients in a more targeted way than nodal sampling alone. Therefore, we recommend use of the SNP in addition to clinical and radiological nodal assessment for pediatric patients with extremity RMS.
KW - Child
KW - Extremities/pathology
KW - Humans
KW - Lymph Node Excision
KW - Lymph Nodes/pathology
KW - Neoplasm Staging
KW - Retrospective Studies
KW - Rhabdomyosarcoma/pathology
KW - Sentinel Lymph Node/pathology
KW - Sentinel Lymph Node Biopsy
UR - http://www.scopus.com/inward/record.url?scp=85107342688&partnerID=8YFLogxK
U2 - 10.1245/s10434-021-10035-9
DO - 10.1245/s10434-021-10035-9
M3 - Article
C2 - 34057567
SN - 1068-9265
VL - 28
SP - 9048
EP - 9059
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 13
ER -