Vascular endothelial growth factor-A165 induces progression of melanoma brain metastases without induction of sprouting angiogenesis

Benno Küsters, William P.J. Leenders, Pieter Wesseling, Debby Smits, Kiek Verrijp, Dirk J. Ruiter, Johannes P.W. Peters, Albert J. Van der Kogel, Robert M.W. De Waal

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

144 Citaten (Scopus)

Samenvatting

We investigated the mechanisms of vascularization in a brain metastases model of malignant melanoma. Parenchymal metastases expressing little vascular endothelial growth factor-A (VEGF-A) co-opted the preexistent brain vasculature, leading to an infiltrative phenotype. Metastases of the human melanoma cell line Mell57, engineered to express recombinant VEGF-A165, showed accelerated growth in a combined expansive and infiltrative pattern with marked central necrosis. This difference in growth profile was accompanied by dilation of co-opted intra- and peritumoral vessels with concomitant induction of vascular permeability. Our data show that modulation of preexistent vasculature can contribute to malignant progression without induction of sprouting angiogenesis.

Originele taal-2Engels
Pagina's (van-tot)341-345
Aantal pagina's5
TijdschriftCancer Research
Volume62
Nummer van het tijdschrift2
StatusGepubliceerd - 15 jan. 2002
Extern gepubliceerdJa

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