TY - JOUR
T1 - Vascular endothelial growth factor-A165 induces progression of melanoma brain metastases without induction of sprouting angiogenesis
AU - Küsters, Benno
AU - Leenders, William P.J.
AU - Wesseling, Pieter
AU - Smits, Debby
AU - Verrijp, Kiek
AU - Ruiter, Dirk J.
AU - Peters, Johannes P.W.
AU - Van der Kogel, Albert J.
AU - De Waal, Robert M.W.
PY - 2002/1/15
Y1 - 2002/1/15
N2 - We investigated the mechanisms of vascularization in a brain metastases model of malignant melanoma. Parenchymal metastases expressing little vascular endothelial growth factor-A (VEGF-A) co-opted the preexistent brain vasculature, leading to an infiltrative phenotype. Metastases of the human melanoma cell line Mell57, engineered to express recombinant VEGF-A165, showed accelerated growth in a combined expansive and infiltrative pattern with marked central necrosis. This difference in growth profile was accompanied by dilation of co-opted intra- and peritumoral vessels with concomitant induction of vascular permeability. Our data show that modulation of preexistent vasculature can contribute to malignant progression without induction of sprouting angiogenesis.
AB - We investigated the mechanisms of vascularization in a brain metastases model of malignant melanoma. Parenchymal metastases expressing little vascular endothelial growth factor-A (VEGF-A) co-opted the preexistent brain vasculature, leading to an infiltrative phenotype. Metastases of the human melanoma cell line Mell57, engineered to express recombinant VEGF-A165, showed accelerated growth in a combined expansive and infiltrative pattern with marked central necrosis. This difference in growth profile was accompanied by dilation of co-opted intra- and peritumoral vessels with concomitant induction of vascular permeability. Our data show that modulation of preexistent vasculature can contribute to malignant progression without induction of sprouting angiogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0037081299&partnerID=8YFLogxK
M3 - Article
C2 - 11809675
AN - SCOPUS:0037081299
SN - 0008-5472
VL - 62
SP - 341
EP - 345
JO - Cancer Research
JF - Cancer Research
IS - 2
ER -