TY - JOUR
T1 - Vincristine-induced peripheral neuropathy in children with cancer
T2 - A systematic review
AU - van de Velde, Mirjam E.
AU - Kaspers, Gertjan L.
AU - Abbink, Floor C.H.
AU - Wilhelm, Abraham J.
AU - Ket, Johannes C.F.
AU - van den Berg, Marleen H.
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/6
Y1 - 2017/6
N2 - Vincristine-induced peripheral neuropathy (VIPN) is a dose-limiting side effect of vincristine (VCR) treatment in children, leading to diminished quality of life. Much remains unknown about the underlying mechanisms of VIPN. This review systematically summarizes the available literature concerning contributing factors of VIPN development in children. Studied factors include patient characteristics, VCR dose, administration method, pharmacokinetics, and genetic factors. Furthermore, this review reports on currently available tools to assess VIPN in children. In total, twenty-eight publications were included. Results indicate that Caucasian race, higher VCR dose, older age and low clearance negatively influence VIPN, although results regarding the latter two factors were rather conflicting. Moreover, genetic pathways influencing VIPN were identified. Furthermore, the studied tools to assess VIPN seriously impairs comparability across study results. Studying the factors and their interactions that seem to influence VIPN in children, should aid in personalized VCR treatment, thereby increasing VCR effectiveness while minimizing toxicity.
AB - Vincristine-induced peripheral neuropathy (VIPN) is a dose-limiting side effect of vincristine (VCR) treatment in children, leading to diminished quality of life. Much remains unknown about the underlying mechanisms of VIPN. This review systematically summarizes the available literature concerning contributing factors of VIPN development in children. Studied factors include patient characteristics, VCR dose, administration method, pharmacokinetics, and genetic factors. Furthermore, this review reports on currently available tools to assess VIPN in children. In total, twenty-eight publications were included. Results indicate that Caucasian race, higher VCR dose, older age and low clearance negatively influence VIPN, although results regarding the latter two factors were rather conflicting. Moreover, genetic pathways influencing VIPN were identified. Furthermore, the studied tools to assess VIPN seriously impairs comparability across study results. Studying the factors and their interactions that seem to influence VIPN in children, should aid in personalized VCR treatment, thereby increasing VCR effectiveness while minimizing toxicity.
KW - Chemotherapeutic
KW - Neurotoxicity
KW - Oncology
KW - Pediatrics
KW - Peripheral neuropathy
KW - Vincristine
UR - http://www.scopus.com/inward/record.url?scp=85018726395&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2017.04.004
DO - 10.1016/j.critrevonc.2017.04.004
M3 - Review article
C2 - 28477739
AN - SCOPUS:85018726395
SN - 1040-8428
VL - 114
SP - 114
EP - 130
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
ER -