Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease

Veronica van der Land; Channa T. Hijmans; Marieke de Ruiter; Henri J.M.M. Mutsaerts; Marjon H. Cnossen; Marc Engelen; Charles B.L.M. Majoie; Aart J. Nederveen; Martha A. Grootenhuis; Karin Fijnvandraat

doi:10.1111/bjh.13179

Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease

Veronica van der Land, Channa T. Hijmans, Marieke de Ruiter, Henri J.M.M. Mutsaerts, Marjon H. Cnossen, Marc Engelen, Charles B.L.M. Majoie, Aart J. Nederveen, Martha A. Grootenhuis, Karin Fijnvandraat

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

58 Citaten (Scopus)

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Summary: Sickle cell disease can be complicated by cerebral white matter hyperintensities (WMHs), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMHs on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 12·5 years) we demonstrated that a higher volume of WMHs was associated with lower full-scale intelligence quotient (IQ), verbal IQ, Processing Speed Index and more fatigue. Our results suggest that volume of WMHs is an additional parameter to take into account when planning individual diagnostic and treatment options.

Originele taal-2	Engels
Pagina's (van-tot)	553-556
Aantal pagina's	4
Tijdschrift	British Journal of Haematology
Volume	168
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1111/bjh.13179
Status	Gepubliceerd - 1 feb. 2015
Extern gepubliceerd	Ja

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van der Land, V., Hijmans, C. T., de Ruiter, M., Mutsaerts, H. J. M. M., Cnossen, M. H., Engelen, M., Majoie, C. B. L. M., Nederveen, A. J., Grootenhuis, M. A., & Fijnvandraat, K. (2015). Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease. British Journal of Haematology, 168(4), 553-556. https://doi.org/10.1111/bjh.13179

@article{9c74cc0327c940e0b76f70752a6e4a76,

title = "Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease",

abstract = "Summary: Sickle cell disease can be complicated by cerebral white matter hyperintensities (WMHs), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMHs on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 12·5 years) we demonstrated that a higher volume of WMHs was associated with lower full-scale intelligence quotient (IQ), verbal IQ, Processing Speed Index and more fatigue. Our results suggest that volume of WMHs is an additional parameter to take into account when planning individual diagnostic and treatment options.",

keywords = "Neurocognitive functioning, Sickle cell disease, Silent cerebral infarcts",

author = "{van der Land}, Veronica and Hijmans, {Channa T.} and {de Ruiter}, Marieke and Mutsaerts, {Henri J.M.M.} and Cnossen, {Marjon H.} and Marc Engelen and Majoie, {Charles B.L.M.} and Nederveen, {Aart J.} and Grootenhuis, {Martha A.} and Karin Fijnvandraat",

note = "Publisher Copyright: {\textcopyright} 2014 John Wiley & Sons Ltd.",

year = "2015",

month = feb,

day = "1",

doi = "10.1111/bjh.13179",

language = "English",

volume = "168",

pages = "553--556",

journal = "British Journal of Haematology",

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van der Land, V, Hijmans, CT, de Ruiter, M, Mutsaerts, HJMM, Cnossen, MH, Engelen, M, Majoie, CBLM, Nederveen, AJ, Grootenhuis, MA & Fijnvandraat, K 2015, 'Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease', British Journal of Haematology, vol. 168, nr. 4, blz. 553-556. https://doi.org/10.1111/bjh.13179

Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease. / van der Land, Veronica; Hijmans, Channa T.; de Ruiter, Marieke et al.
In: British Journal of Haematology, Vol. 168, Nr. 4, 01.02.2015, blz. 553-556.

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

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T1 - Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease

AU - van der Land, Veronica

AU - Hijmans, Channa T.

AU - de Ruiter, Marieke

AU - Mutsaerts, Henri J.M.M.

AU - Cnossen, Marjon H.

AU - Engelen, Marc

AU - Majoie, Charles B.L.M.

AU - Nederveen, Aart J.

AU - Grootenhuis, Martha A.

AU - Fijnvandraat, Karin

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Summary: Sickle cell disease can be complicated by cerebral white matter hyperintensities (WMHs), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMHs on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 12·5 years) we demonstrated that a higher volume of WMHs was associated with lower full-scale intelligence quotient (IQ), verbal IQ, Processing Speed Index and more fatigue. Our results suggest that volume of WMHs is an additional parameter to take into account when planning individual diagnostic and treatment options.

AB - Summary: Sickle cell disease can be complicated by cerebral white matter hyperintensities (WMHs), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMHs on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 12·5 years) we demonstrated that a higher volume of WMHs was associated with lower full-scale intelligence quotient (IQ), verbal IQ, Processing Speed Index and more fatigue. Our results suggest that volume of WMHs is an additional parameter to take into account when planning individual diagnostic and treatment options.

KW - Neurocognitive functioning

KW - Sickle cell disease

KW - Silent cerebral infarcts

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Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease

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