White paper on the current state of imaging biomarkers in paediatric oncology

Rutger A.J. Nievelstein; Lise Borgwardt; Emilio J. Inarejos Clemente; Thekla Von Kalle; Martin Kyncl; Maarten H. Lequin; Annemieke S. Littooij; Erika Pace; Pier L. Di Paolo; Rick R. Van Rijn; Julian M.M. Rogasch; Jurgen Schäfer; Irmina Sefic Pasic; Anita Spezzacatene; Nelleke Tolboom; Simon M. Wan; Pietro Zucchetta

doi:10.1007/s00247-025-06372-6

White paper on the current state of imaging biomarkers in paediatric oncology

Rutger A.J. Nievelstein
, Lise Borgwardt
, Emilio J. Inarejos Clemente
, Thekla Von Kalle
, Martin Kyncl
, Maarten H. Lequin
, Annemieke S. Littooij
, Erika Pace
, Pier L. Di Paolo
, Rick R. Van Rijn
, Julian M.M. Rogasch
, Jurgen Schäfer
, Irmina Sefic Pasic
, Anita Spezzacatene
, Nelleke Tolboom
, Simon M. Wan
, Pietro Zucchetta

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

Samenvatting

In paediatric oncology, imaging biomarkers play an increasing role in diagnostic imaging and research. They can be used for prediction, detection, staging, and grading of diseases, as well as for assessment of response to treatment. Imaging biomarkers are complementary to tissue-based biomarkers, enabling a more personalised approach in oncology care. In this white paper by the European Society of Paediatric Radiology (ESPR) Oncology Taskforce and European Association of Nuclear Medicine (EANM) Paediatrics Committee, an overview is given of the current knowledge on the use of imaging biomarkers in general and per tumour group.

Originele taal-2	Engels
Pagina's (van-tot)	2493-2507
Aantal pagina's	15
Tijdschrift	Pediatric Radiology
Volume	55
Nummer van het tijdschrift	12
DOI's	https://doi.org/10.1007/s00247-025-06372-6
Status	Gepubliceerd - nov. 2025
Extern gepubliceerd	Ja

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10.1007/s00247-025-06372-6

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Nievelstein, R. A. J., Borgwardt, L., Inarejos Clemente, E. J., Von Kalle, T., Kyncl, M., Lequin, M. H., Littooij, A. S., Pace, E., Di Paolo, P. L., Van Rijn, R. R., Rogasch, J. M. M., Schäfer, J., Sefic Pasic, I., Spezzacatene, A., Tolboom, N., Wan, S. M., & Zucchetta, P. (2025). White paper on the current state of imaging biomarkers in paediatric oncology. Pediatric Radiology, 55(12), 2493-2507. https://doi.org/10.1007/s00247-025-06372-6

@article{db53b88678034b3bbc185c40b3acf345,

title = "White paper on the current state of imaging biomarkers in paediatric oncology",

abstract = "In paediatric oncology, imaging biomarkers play an increasing role in diagnostic imaging and research. They can be used for prediction, detection, staging, and grading of diseases, as well as for assessment of response to treatment. Imaging biomarkers are complementary to tissue-based biomarkers, enabling a more personalised approach in oncology care. In this white paper by the European Society of Paediatric Radiology (ESPR) Oncology Taskforce and European Association of Nuclear Medicine (EANM) Paediatrics Committee, an overview is given of the current knowledge on the use of imaging biomarkers in general and per tumour group.",

keywords = "Biomarkers, Child, Diagnostic imaging, Nuclear medicine, Oncology, Radiology, Radionuclide imaging, Pediatrics, Humans, Biomarkers, Tumor, Medical Oncology, Societies, Medical, Diagnostic Imaging/methods, Neoplasms/diagnostic imaging",

author = "Nievelstein, \{Rutger A.J.\} and Lise Borgwardt and \{Inarejos Clemente\}, \{Emilio J.\} and \{Von Kalle\}, Thekla and Martin Kyncl and Lequin, \{Maarten H.\} and Littooij, \{Annemieke S.\} and Erika Pace and \{Di Paolo\}, \{Pier L.\} and \{Van Rijn\}, \{Rick R.\} and Rogasch, \{Julian M.M.\} and Jurgen Sch{\"a}fer and \{Sefic Pasic\}, Irmina and Anita Spezzacatene and Nelleke Tolboom and Wan, \{Simon M.\} and Pietro Zucchetta",

note = "{\textcopyright} 2025. The Author(s).",

year = "2025",

month = nov,

doi = "10.1007/s00247-025-06372-6",

language = "English",

volume = "55",

pages = "2493--2507",

journal = "Pediatric Radiology",

issn = "0301-0449",

publisher = "Springer Nature",

number = "12",

}

Nievelstein, RAJ, Borgwardt, L, Inarejos Clemente, EJ, Von Kalle, T, Kyncl, M, Lequin, MH, Littooij, AS, Pace, E, Di Paolo, PL, Van Rijn, RR, Rogasch, JMM, Schäfer, J, Sefic Pasic, I, Spezzacatene, A, Tolboom, N, Wan, SM & Zucchetta, P 2025, 'White paper on the current state of imaging biomarkers in paediatric oncology', Pediatric Radiology, vol. 55, nr. 12, blz. 2493-2507. https://doi.org/10.1007/s00247-025-06372-6

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T1 - White paper on the current state of imaging biomarkers in paediatric oncology

AU - Nievelstein, Rutger A.J.

AU - Borgwardt, Lise

AU - Inarejos Clemente, Emilio J.

AU - Von Kalle, Thekla

AU - Kyncl, Martin

AU - Lequin, Maarten H.

AU - Littooij, Annemieke S.

AU - Pace, Erika

AU - Di Paolo, Pier L.

AU - Van Rijn, Rick R.

AU - Rogasch, Julian M.M.

AU - Schäfer, Jurgen

AU - Sefic Pasic, Irmina

AU - Spezzacatene, Anita

AU - Tolboom, Nelleke

AU - Wan, Simon M.

AU - Zucchetta, Pietro

PY - 2025/11

Y1 - 2025/11

N2 - In paediatric oncology, imaging biomarkers play an increasing role in diagnostic imaging and research. They can be used for prediction, detection, staging, and grading of diseases, as well as for assessment of response to treatment. Imaging biomarkers are complementary to tissue-based biomarkers, enabling a more personalised approach in oncology care. In this white paper by the European Society of Paediatric Radiology (ESPR) Oncology Taskforce and European Association of Nuclear Medicine (EANM) Paediatrics Committee, an overview is given of the current knowledge on the use of imaging biomarkers in general and per tumour group.

AB - In paediatric oncology, imaging biomarkers play an increasing role in diagnostic imaging and research. They can be used for prediction, detection, staging, and grading of diseases, as well as for assessment of response to treatment. Imaging biomarkers are complementary to tissue-based biomarkers, enabling a more personalised approach in oncology care. In this white paper by the European Society of Paediatric Radiology (ESPR) Oncology Taskforce and European Association of Nuclear Medicine (EANM) Paediatrics Committee, an overview is given of the current knowledge on the use of imaging biomarkers in general and per tumour group.

KW - Biomarkers

KW - Child

KW - Diagnostic imaging

KW - Nuclear medicine

KW - Oncology

KW - Radiology

KW - Radionuclide imaging

KW - Pediatrics

KW - Humans

KW - Biomarkers, Tumor

KW - Medical Oncology

KW - Societies, Medical

KW - Diagnostic Imaging/methods

KW - Neoplasms/diagnostic imaging

UR - https://www.scopus.com/pages/publications/105015099518

UR - https://www.mendeley.com/catalogue/c22fb0d4-9271-30a7-8c04-946e3a5d110a/

U2 - 10.1007/s00247-025-06372-6

DO - 10.1007/s00247-025-06372-6

M3 - Review article

C2 - 40892085

AN - SCOPUS:105015099518

SN - 0301-0449

VL - 55

SP - 2493

EP - 2507

JO - Pediatric Radiology

JF - Pediatric Radiology

IS - 12

ER -

White paper on the current state of imaging biomarkers in paediatric oncology

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