Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline

Keyphrases

• Tumor 100%
• Mutational Processes 100%
• Whole Genome Sequencing 100%
• Spermatocytic Seminoma 100%
• Male Germ Cells 100%
• Germ Cells 40%
• Aneuploidy 40%
• Etiology 40%
• Spermatogonia 40%
• Evolutionary Constraint 40%
• Cellular Origin 20%
• Mutational Signatures 20%
• Mitosis 20%
• Single nucleotide Variant 20%
• Driver Events 20%
• Fibroblast Growth Factor Receptor 3 (FGFR3) 20%
• Genome Integrity 20%
• Mutation Rate 20%
• Adult Male 20%
• Mutational Landscape 20%
• NRAS mutation 20%
• Point mutation 20%
• Puberty 20%
• Trinucleotide 20%
• Tumor Pathology 20%
• Spermatocyte 20%
• Unique Properties 20%
• Male Germ Cell Tumor 20%
• Candidate Gene Study 20%
• De-novo mutations 20%
• Meiosis 20%
• Spermatozoa 20%
• Autosomes 20%
• Sex Chromosome Aneuploidy 20%
• Male Germline Stem Cells (mGSCs) 20%
• Variant Load 20%
• Synonymous Variant 20%

Biochemistry, Genetics and Molecular Biology

• Whole Genome Sequencing 100%
• Germline 100%
• Germ Cell 100%
• Aneuploidy 75%
• Spermatogonium 50%
• Evolution 50%
• Candidate Gene 25%
• Mutation Rate 25%
• Stem Cell 25%
• Single-Nucleotide Polymorphism 25%
• Fibroblast Growth Factor Receptor 3 25%
• Autosome 25%
• Point Mutation 25%
• Meiosis 25%
• HRAS 25%