Wnt/β-catenin signaling and disease

Hans Clevers; Roel Nusse

doi:10.1016/j.cell.2012.05.012

Wnt/β-catenin signaling and disease

Hans Clevers
, Roel Nusse

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › Onderzoek › peer review

5112 Citaten (Scopus)

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The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

Originele taal-2	Engels
Pagina's (van-tot)	1192-1205
Aantal pagina's	14
Tijdschrift	Cell
Volume	149
Nummer van het tijdschrift	6
DOI's	https://doi.org/10.1016/j.cell.2012.05.012
Status	Gepubliceerd - 8 jun 2012
Extern gepubliceerd	Ja

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10.1016/j.cell.2012.05.012

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abstract = "The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.",

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M3 - Review article

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Wnt/β-catenin signaling and disease

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