Wnt/β-catenin signaling and disease

Hans Clevers; Roel Nusse

doi:10.1016/j.cell.2012.05.012

Wnt/β-catenin signaling and disease

Hans Clevers, Roel Nusse

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

4831 Citaten (Scopus)

Samenvatting

The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

Originele taal-2	Engels
Pagina's (van-tot)	1192-1205
Aantal pagina's	14
Tijdschrift	Cell
Volume	149
Nummer van het tijdschrift	6
DOI's	https://doi.org/10.1016/j.cell.2012.05.012
Status	Gepubliceerd - 8 jun. 2012
Extern gepubliceerd	Ja

Toegang tot document

10.1016/j.cell.2012.05.012

Citeer dit

@article{e30bf18fb1c3461caf653a7c0a42a86e,

title = "Wnt/β-catenin signaling and disease",

abstract = "The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.",

author = "Hans Clevers and Roel Nusse",

year = "2012",

month = jun,

day = "8",

doi = "10.1016/j.cell.2012.05.012",

language = "English",

volume = "149",

pages = "1192--1205",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Wnt/β-catenin signaling and disease

AU - Clevers, Hans

AU - Nusse, Roel

PY - 2012/6/8

Y1 - 2012/6/8

N2 - The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

AB - The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

UR - https://www.scopus.com/pages/publications/84861986053

U2 - 10.1016/j.cell.2012.05.012

DO - 10.1016/j.cell.2012.05.012

M3 - Review article

C2 - 22682243

AN - SCOPUS:84861986053

SN - 0092-8674

VL - 149

SP - 1192

EP - 1205

JO - Cell

JF - Cell

IS - 6

ER -

Wnt/β-catenin signaling and disease

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit