Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Roel Nusse; Hans Clevers

doi:10.1016/j.cell.2017.05.016

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Roel Nusse, Hans Clevers

Group Clevers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

3052 Citaten (Scopus)

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The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

Originele taal-2	Engels
Pagina's (van-tot)	985-999
Aantal pagina's	15
Tijdschrift	Cell
Volume	169
Nummer van het tijdschrift	6
DOI's	https://doi.org/10.1016/j.cell.2017.05.016
Status	Gepubliceerd - 1 jun. 2017

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10.1016/j.cell.2017.05.016

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abstract = "The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.",

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Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

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