Wnt/β-catenin signaling in adult mammalian epithelial stem cells

Kai Kretzschmar, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

107 Citaten (Scopus)


Adult stem cells self-renew and replenish differentiated cells in various organs and tissues throughout a mammal's life. Over the last 25 years an ever-growing body of knowledge has unraveled the essential regulation of adult mammalian epithelia by the canonical Wnt signaling with its key intracellular effector β-catenin. In this review, we discuss the principles of the signaling pathway and its role in adult epithelial stem cells of the intestine and skin during homeostasis and tumorigenesis. We further highlight the research that led to the identification of new stem cell markers and methods to study adult stem cells ex vivo.

Originele taal-2Engels
Pagina's (van-tot)273-282
Aantal pagina's10
TijdschriftDevelopmental Biology
Nummer van het tijdschrift2
StatusGepubliceerd - 15 aug. 2017


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