Wnt acylation and its functional implication in Wnt signalling regulation

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

33 Citaten (Scopus)

Samenvatting

Wnt proteins are conserved signalling molecules that have an essential role in regulating diverse processes during embryogenesis and adult tissue homoeostasis. Wnts are post-translationally modified by palmitoylation, which is essential for Wnt secretion and function. Intriguingly, the crystal structure of XWnt8 in complex with the extracellular domain of the Frizzled 8 cysteine-rich domain (Fzd8-CRD) revealed that Wnts use the fatty acid as a 'hotspot' residue to engage its receptor, which is a unique mode of receptor-ligand recognition. In addition, there are several lines of evidence suggesting that Wnts engage several signalling modulators and alternative receptors by means of fatty acids as a critical contact residue. In the present article, we review our current understanding of Wnt acylation and its functional role in Wnt signalling regulation.

Originele taal-2Engels
Pagina's (van-tot)211-216
Aantal pagina's6
TijdschriftBiochem Soc Trans
Volume43
DOI's
StatusGepubliceerd - apr. 2015
Extern gepubliceerdJa

Vingerafdruk

Duik in de onderzoeksthema's van 'Wnt acylation and its functional implication in Wnt signalling regulation'. Samen vormen ze een unieke vingerafdruk.

Citeer dit